April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Major Eye Diseases and Risk Factors Associated With Hypertension in an Adult Chinese Population. The Beijing Eye Study
S. Wang; L. Xu; J. Jonas; T. Wong; T. Cui; Y. Li; Y. Wang; Q. You; H. Yang; C. Sun
Author Affiliations & Notes
  • S. Wang
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • L. Xu
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • J. Jonas
    Ophthalmology, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
  • T. Wong
    Ophthalmology, Royal Victorian Eye & Ear Hospital, Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • T. Cui
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • Y. Li
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • Y. Wang
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • Q. You
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • H. Yang
    Ophthalmology, Beijing Institute of Ophthalmology, Beijing, China
  • C. Sun
    Ophthalmology, Royal Victorian Eye & Ear Hospital, Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  • Footnotes
    Commercial Relationships  S. Wang, None; L. Xu, None; J. Jonas, None; T. Wong, None; T. Cui, None; Y. Li, None; Y. Wang, None; Q. You, None; H. Yang, None; C. Sun, None.
  • Footnotes
    Support  Beijing Municipal Natural Science Foundation AND Projects of International Cooperation of Beijing Municipal Science and Technology Commission
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3723. doi:
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      S. Wang, L. Xu, J. Jonas, T. Wong, T. Cui, Y. Li, Y. Wang, Q. You, H. Yang, C. Sun; Major Eye Diseases and Risk Factors Associated With Hypertension in an Adult Chinese Population. The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3723.

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Abstract

Purpose: : To assess relationships between hypertension with major eye diseases and ocular parameters.

Methods: : Design. Population-based study. Participants. The Beijing Eye Study is a population-based study which included 4439 Chinese subjects examined at the baseline examination in 2001, with a follow-up examination in 2006, in which 3251 subjects participated, and 3222 had blood pressure measurements. All participants underwent an ophthalmic examination, anthropometric measurements and blood pressure measurements. Hypertension was defined as a systolic blood pressure ≥ 140 mm Hg and/or a diastolic blood pressure ≥ 90 mm Hg, and/or self-reported current treatment for hypertension with antihypertensive medication.

Results: : The mean age of participants was 60.4 years. Hypertension was present in 1500 (46.6%) subjects. In multiple regression analysis, the hypertension was significantly associated with higher intraocular pressure (P<0.001; Odds ratio (OR): 1.08; 95% Confidence intervals (CI): 1.05, 1.11), focal arteriolar narrowing (P=0.001; OR: 1.64; 95%CI: 1.21, 2.22;), arterio-venous nicking (P<0.001; OR: 1.48; 95%CI: 1.10, 2.01), generalized retinal arteriolar narrowing (P<0.001; OR: 1.73; 95%CI: 1.40, 2.14), and diabetic retinopathy (P=0.016; OR: 2.18; 95%CI: 1.15, 4.11). Hypertension was not significantly associated with the prevalence of open-angle glaucoma (P=0.19) or angle-closure glaucoma (P=0.96), age-related macular degeneration (P=0.07), retinal vein occlusion (P=0.33), nuclear cataract (P=0.84), posterior subcapsular cataract (P=0.34), cortical cataract (P=0.05), and area of neuroretinal rim (P=0.99), alpha zone (P=0.05) and beta zone of parapapillary atrophy (P=0.64).

Conclusions: : After adjusting for other systemic parameters, hypertension was associated with increased intraocular pressure, retinal microvascular abnormalities and diabetic retinopathy. Hypertension was not significantly associated with age-related macular degeneration, age-related cataract, and glaucoma.

Keywords: clinical (human) or epidemiologic studies: risk factor assessment • intraocular pressure • retina 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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