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S. Wang, L. Xu, J. Jonas, T. Wong, T. Cui, Y. Li, Y. Wang, Q. You, H. Yang, C. Sun; Major Eye Diseases and Risk Factors Associated With Hypertension in an Adult Chinese Population. The Beijing Eye Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3723.
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© ARVO (1962-2015); The Authors (2016-present)
To assess relationships between hypertension with major eye diseases and ocular parameters.
Design. Population-based study. Participants. The Beijing Eye Study is a population-based study which included 4439 Chinese subjects examined at the baseline examination in 2001, with a follow-up examination in 2006, in which 3251 subjects participated, and 3222 had blood pressure measurements. All participants underwent an ophthalmic examination, anthropometric measurements and blood pressure measurements. Hypertension was defined as a systolic blood pressure ≥ 140 mm Hg and/or a diastolic blood pressure ≥ 90 mm Hg, and/or self-reported current treatment for hypertension with antihypertensive medication.
The mean age of participants was 60.4 years. Hypertension was present in 1500 (46.6%) subjects. In multiple regression analysis, the hypertension was significantly associated with higher intraocular pressure (P<0.001; Odds ratio (OR): 1.08; 95% Confidence intervals (CI): 1.05, 1.11), focal arteriolar narrowing (P=0.001; OR: 1.64; 95%CI: 1.21, 2.22;), arterio-venous nicking (P<0.001; OR: 1.48; 95%CI: 1.10, 2.01), generalized retinal arteriolar narrowing (P<0.001; OR: 1.73; 95%CI: 1.40, 2.14), and diabetic retinopathy (P=0.016; OR: 2.18; 95%CI: 1.15, 4.11). Hypertension was not significantly associated with the prevalence of open-angle glaucoma (P=0.19) or angle-closure glaucoma (P=0.96), age-related macular degeneration (P=0.07), retinal vein occlusion (P=0.33), nuclear cataract (P=0.84), posterior subcapsular cataract (P=0.34), cortical cataract (P=0.05), and area of neuroretinal rim (P=0.99), alpha zone (P=0.05) and beta zone of parapapillary atrophy (P=0.64).
After adjusting for other systemic parameters, hypertension was associated with increased intraocular pressure, retinal microvascular abnormalities and diabetic retinopathy. Hypertension was not significantly associated with age-related macular degeneration, age-related cataract, and glaucoma.
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