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S. Arakawa, M. Yasuda, Y. Kiyohara, Y. Hata, T. Ishibashi; Nine-Year Incidence and Risk Factors for Retinal Vein Occlusion in a General Japanese Population: The Hisayama Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3727.
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To estimate the 9-year incidence and risk factors for retinal vein occlusion (RVO) in a defined Japanese population.
In 1998, a total of 1,775 Hisayama residents aged 40 years or older underwent a baseline eye examination. Of those, 1,401 subjects (78.9%) took part in the follow-up eye examination in 2007 and were enrolled in the present study. At both time points, the characteristics of RVO were determined by grading color fundus photographs.
After excluding 38 participants with RVO at the baseline eye examination, a total of 27 participants (2.0%) developed incident RVO during the follow-up.The 9-year cumulative incidence of branch RVO was 1.9%, and that of central RVO was 0.07%. Hypertension (OR, 2.18; 95% CI, 1.00 to 4.73), and diastolic blood pressure (OR, 1.51; 95% CI, 1.09 to 2.09) were significantly associated with the development of RVO.
Our findings suggest that the 9-year incidence of RVO among Japanese is higher than that among people in Western countries and the other Asian countries. Hypertension, especially diastolic blood pressure, is significant risk factor for the development of RVO in Japanese.
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