April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Focal Macular Changes in Glaucomatous Patients Detected by Spectral Domain OCT
Author Affiliations & Notes
  • A. M. Coppe
    Ophthalmology, GB Foundation Study Ophth IRCCS, Rome, Italy
  • G. Lapucci
    National Research Council, Rome, Italy
  • M. Sciamanna
    Ophthalmology, GB Foundation Study Ophth IRCCS, Rome, Italy
  • Footnotes
    Commercial Relationships  A.M. Coppe, None; G. Lapucci, None; M. Sciamanna, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 3810. doi:
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      A. M. Coppe, G. Lapucci, M. Sciamanna; Focal Macular Changes in Glaucomatous Patients Detected by Spectral Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3810.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To detect damage to specific macular areas in glaucomatous patients by optical coherence tomography (OCT)

Methods: : 11 eyes of 11 patients with perimetric glaucoma (PGEs), mean age 56±12 years, 7F and 4M, were studied. 11 eyes randomly selected in 11 healthy, age-matched, subjects were used as control eyes (CEs). All subjects had ametropia < 2D and underwent clinical examination including VA evaluation using ETDRS chart, slit-lamp biomicroscopy with +90 D lens and visual field testing. Macular morphology was studied with a high resolution spectral domain (SD) OCT Cirrus (Carl Zeiss Meditec, Inc., Dublin, CA) using Macular Cube 512x128 test; the Cirrus segmentation algorithm produced retinal thickness maps, which were averaged over 9 regions defined by a circular target centered at the fovea location. The 9 regions were: fovea (F); superior (sIM), inferior (iIM), temporal (tIM), nasal inner macula (nIM); and superior (sOM), inferior (iOM), temporal (tOM), nasal outer macula (nOM); total macular volume (tMV) was also calculated. Thickess measurements of homologous areas were compared to those of CEs. Data were analysed by one-way ANOVA. A level of p<0.05 was accepted as statistically significant.

Results: : sIM, nIM, sOM, nOM, iOM and tMV were significantly thinner in PGEs than in the CEs (p=0.029, p=0.036, p=0.030, p=0.010, p=0.032, p=0.021, respectively). iIM and tIM reduction was not significant (p=0.058, p=0.053, respectively). F and tOM were unaffected (p=0.240, p=0.167, respectively).

Conclusions: : Reported data show that, even if a diffuse macular thinning occurs in glaucomatous eyes, the main cellular loss is concentrated in specific areas of the retina: a selective damage occurs in papillo-macular region (nOM and nIM), where the density of ganglion cells is higher. An accurate imaging of specific macular structures is now possible with SD-OCT; as the damage in glaucomatous eyes involves since the beginning specific macular areas, we believe a careful study of these areas can be useful for an earlier diagnosis and to monitor the progression of the disease.

Keywords: macula/fovea • ganglion cells • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 

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