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A. R. Santos, R. Bernardes, R. Silva, S. Nunes, P. Fonseca, S. Carvajal-Gonzalez, R. Buggage, J. Cunha-Vaz; Alteration of the Blood-Retinal Barrier Identified by Retinal Leakage Analysis Is a Predictor for Conversion to Wet Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2009;50(13):3920.
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To identify in a two-year longitudinal and observational study the occurrence of alterations of the Blood-Retinal Barrier (BRB), and their relation with the development of choroidal neovascularization (CNV) lesions.
Sixty-two patients with unilateral CNV and dry age-related macular degeneration (AMD) in the study eye have been followed in a two-year prospective, observational, longitudinal study. Examinations were performed at baseline and every 6 months thereafter. To characterize and identify CNV development we performed best corrected ETDRS visual acuity, OCT, fluorescein (SLO.FA) and indocyanine green angiography, fundus photography, fundus autofluorescence imaging and Retinal Leakage Analyzer (RLA) using methods and proprietary software (Bernardes, IEEE-TBME, 2005). The observations made in the study eyes that did develop CNV during the follow-up are reported.
Fifty-two patients completed the study according the protocol. Seventeen developed CNV in the fellow eye during this period. Alterations in the SLO.FA were used to identify conversion to wet age-related macular degeneration (AMD). RLA failed to process in 3 eyes but demonstrated the presence of varying degrees of alteration of BRB in every one of the remaining 14 eyes that converted to wet AMD. There were alterations of the BRB in 11 eyes at every visit before the conversion visit and in the other 3 in the visit before conversion.
Fellow eyes of patients with wet AMD in the other eye that developed CNV during a two-year prospective study showed consistently alterations of BRB, identified by RLA Analysis, before conversion. Alterations of BRB appear to predict development of CNV.
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