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M. Schargus, E. Gramer; Increased Risk in Patients With Optic Disk Drusen for an Acute Non Arteritic Anterior Ischemic Optic Neuropathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4023.
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To evaluate: 1. the prevalence of NAION in patients with ODD 2. risk factors compared to control groups.
120 patients with uni- or bilateral ultrasonographic confirmed ODD were prospectively, consecutively examined and standardized documented between 1987 and 2008. We evaluated whether there are any significant differences between three patient groups: 1. 14 patients with ODD and NAION, 2. 106 patients with ODD without NAION, 3. 420 patients from literature (1) with NAION without ODD in: age of the patient at diagnosis, gender, vascular risk factors (hypertension, heart attack, cardiopathy, hyperlipidemia), visual acuity (VA), mean stage of visual field loss (VFL) and topography of VFL. Unpaired t-test was used for statistics.
1. 14 out of 120 patients with ODD presented at diagnosis an acute unilateral NAION (10.3%).2. Mean age at diagnosis: Patients with ODD and NAION were significantly younger than patients with NAION without ODD (43,6±18,9 vs. 66,0±8,7 years)(p=0,06). Patients with ODD without NAION were not significant younger than patients with ODD and NAION (42,5±20,0 vs. 43,6±18,9 years) (p=0,8). Gender distribution showed a higher prevalence of females in all three groups and no significant difference between the three groups (females: 61,5% vs 61.3% vs 61,7%). Vascular risk factors were less frequent in the group with ODD and NAION (36%) compared to patients with NAION without ODD (57,9%). Visual acuity was significantly better in patients with ODD and NAION which had in 79% a visual acuity better than 20/64 than patients with NAION without ODD (35%). Patients with ODD without NAION had in 92,6% a VA better than 20/64. Topography of VFL was similar in all patients with NAION with or without ODD presenting most commonly VFL in the inferior hemifield (57% vs 46 %).
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