April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Clinical Polymorphism of Myasthenia Gravis Beginning With Isolated Ocular Symptoms
Author Affiliations & Notes
  • J. Boumendil
    Necker, paris, France
  • C. Vignal-Clermont
    Rothschild's ophthalmologic foundation, paris, France
  • J. Allali
    Necker, paris, France
  • J.-L. Dufier
    Necker, paris, France
  • S. Morax
    Rothschild's ophthalmologic foundation, paris, France
  • Footnotes
    Commercial Relationships  J. Boumendil, None; C. Vignal-Clermont, None; J. Allali, None; J.-L. Dufier, None; S. Morax, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4035. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. Boumendil, C. Vignal-Clermont, J. Allali, J.-L. Dufier, S. Morax; Clinical Polymorphism of Myasthenia Gravis Beginning With Isolated Ocular Symptoms. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4035.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : the aim of this study is to highlight the clinical diversity of myasthenia gravis beginning with isolated ocular symptoms.

Methods: : we present a 15 patients series that we have been taking care of at Rothschild’s Ophthalmologic Foundation from 2002 to 2007. Every patients have been examinated by the same ophthalmologist for isolated ocular symptoms. An acetylcholin-receptor antibodies research, a cerebral RMI and a chest tomography have been systematically realized.

Results: : When the disease was diagnosed, 11 patients out of 15 had a ptosis with a diplopia, 2 had an isolated ptosis and 2 had an isolated diplopia. After investigations, we discovered that three patients had a malignant thymoma and one had a thymic hyperplasia. An autoimmune disease association has been found with 2 patients: the first one had a Hashimoto’s thyroiditis and the second one has developed an optical neuro-myelitis few years after his myasthenia gravis. Only three patients secondarily developed a generalized myasthenia gravis. This could be explained by the early attending of these patients, and the common prescription of an immunosuppressive therapy reducing the risk of secondarily generalised myasthenia gravis according to some studies.

Conclusions: : Despite the small number of patients, this study well underlines the clinical polymorphism of ocular myasthenia gravis, the risks it may cause, and the important role of the ophthalmologists in the diagnosis of this disease. Close collaboration between ophthalmologists and neurologists is needed to ensure a well taking care of these patients.

Keywords: neuro-ophthalmology: diagnosis • autoimmune disease • acetylcholine 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.