Abstract
Purpose: :
To investigate the effect of tafluprost on intraocular pressure (IOP) in the ocular normotensive monkeys which dose not well respond to latanoprost.
Methods: :
The animals had been trained to IOP measurement before this experiment. IOP was measured using pneumatonometer under conscious. 0.005% latanoprost and saline were topically administrated once a daily (9:00 - 11:00 a.m.) for 7 days. We defined the monkeys which responded 1 mmHg or less IOP reduction as the latanoprost low-responder. 0.0015% tafluprost and saline were topically administrated once a daily (9:00 - 11:00 a.m.) for 7 days to latanoprost low-responder monkeys.
Results: :
These were 11 latanoprost low-responder monkeys. The baseline IOP before latanoprost administration was 16.6 ± 0.8 mmHg (mean ± S.E.M), and maximal IOP reduction (maximal ΔIOP) was 0.7 ± 0.2 mmHg (Day1) and 0.6 ± 0.1 mmHg (Day7), respectively. Topical administration of tafluprost for 7 days decreased IOP in all latanoprost low-responder monkeys. The baseline IOP before tafluprost administration was 16.5 ± 0.8 mmHg, and maximal ΔIOP was 2.1 ± 0.2 mmHg (Day1) and 2.9 ± 0.2 mmHg (Day7), respectively. The IOP reduction of tafluprost was significant compared with that of saline (Student t-test, p < 0.05).
Conclusions: :
Topical administration of tafluprost decreased IOP in latanoprost low-responder monkeys. This result suggests that tafluprost may be effective medicine for latanoprost low-responder.
Keywords: intraocular pressure