April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Interpretation of Optical Coherent Tomographic Findings in the Rabbit Eye with Implanted Retinal Prosthesis Electrode Arrays
J.-M. Seo; H. Shin; E. Kim; K. Koo; E. Shin; G. J. Suaning; N. H. Lovell; D.-I. Cho; S. Kim; H. Chung
Author Affiliations & Notes
  • J.-M. Seo
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
  • H. Shin
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
  • E. Kim
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
    Electrical Engineering, Seoul National University School of Engineering, Seoul, Republic of Korea
  • K. Koo
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
    Electrical Engineering, Seoul National University School of Engineering, Seoul, Republic of Korea
  • E. Shin
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
  • G. J. Suaning
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
  • N. H. Lovell
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia
  • D.-I. Cho
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
    Electrical Engineering, Seoul National University School of Engineering, Seoul, Republic of Korea
  • S. Kim
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
    Electrical Engineering, Seoul National University School of Engineering, Seoul, Republic of Korea
  • H. Chung
    Ophthalmology, Seoul National University School of Medicine, Seoul, Republic of Korea
    Nano Bioelectronics & Systems Research Center, Nano Artificial Vision Research Center, Seoul National University, Republic of Korea
  • Footnotes
    Commercial Relationships  J.-M. Seo, None; H. Shin, None; E. Kim, None; K. Koo, None; E. Shin, None; G.J. Suaning, None; N.H. Lovell, None; D.-I. Cho, None; S. Kim, None; H. Chung, None.
  • Footnotes
    Support  NBS-ERC supported by KOSEF & Korea Health 21 R&D Project A050251 supported by MIHWAF, NH&MRC, ARC and Retina Australia
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4745. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      Interpretation of Optical Coherent Tomographic Findings in the Rabbit Eye with Implanted Retinal Prosthesis Electrode Arrays
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      J.-M. Seo, H. Shin, E. Kim, K. Koo, E. Shin, G. J. Suaning, N. H. Lovell, D.-I. Cho, S. Kim, H. Chung; Interpretation of Optical Coherent Tomographic Findings in the Rabbit Eye with Implanted Retinal Prosthesis Electrode Arrays. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4745.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Purpose: : Optical coherent tomography (OCT) is a useful method to evaluate the cross-sectional morphology of the retina in vivo. However, the image processing algorithms used in OCT may generate incorrect images from interferometric data. Implanted microelectrode arrays (MEAs) for retinal stimulation were evaluated by OCT and the acquired images were compared with the real dimensional configuration of the MEAs in vivo.

Methods: : New Zealand white rabbits (N=10) weighing 3.0 kg were used for in vivo biocompatibility evaluation of the MEA. Three types of planar MEA (polyimide-based gold electrode, polyimide/silicone-based gold electrode, silicone-based platinum electrode) and two types of polyimide-based 3D MEA (mushroom-shaped gold electrode, arrowhead-shaped gold electrode) were implanted into the subretinal or suprachoroidal space of the rabbit eyes. Spectral domain OCT (CirrusTM) was taken serially for one month and the results were compared with data from cross-sectional microscopic morphology and histology.

Results: : All the electrodes were implanted safely in rabbit eyes. Silicone showed lower reflectance than polyimide, and the polyimide gave lower reflectance than the retinal pigment epithelium but higher reflectance than the inner nuclear layer. Metallic electrodes generated various reflectances with posterior shadow. Instead of revealing indentation or elevation of the retina over the electrode, OCT showed a straight internal limiting membrane line, and paradoxical posterior indentation or deflection of the sclera. Cross-sectional microscopic morphology and the histology confirmed the indentation or elevation of the retina over the electrode.

Conclusions: : Although OCT was a good method to show the relationship between the retina and the implanted MEA, careful interpretation should be made in evaluating in vivo status of MEA in the subretinal or suprachoroidal space of the eye.

Keywords: retina • transplantation • retinal connections, networks, circuitry 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept