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Y. Chen, J. J. Liu, B. Potsaid, V. J. Srinivasan, J. S. Schuman, J. S. Duker, J. G. Fujimoto; Ultrahigh Speed Optical Coherence Tomography Imaging of Human Retina Using Swept Source / Fourier Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4776.
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© ARVO (1962-2015); The Authors (2016-present)
To demonstrate swept source / Fourier domain technology for ultrahigh speed OCT imaging of the retina and optic disc at 250,000 axial scans per second. To investigate imaging factors such as contrast and penetration depth using an alternative 1060 nm central wavelength. To study the improved visualization of the retina, choroid, and optic nerve with reduced motion artifacts by ultrahigh scanning speed enabled by swept source / Fourier domain OCT .
A swept laser operating at 1060 nm central wavelength was developed using Fourier domain modelocking. A swept source / Fourier domain OCT retinal imaging system operating at 250,000 axial scans per second with ~10 um axial resolution was built using this novel laser. Imaging of the retina, choroid, and optic nerve was performed using dense raster scanning. Data processing methods were implemented to generate different views based on the 3D-OCT data sets.
High-definition and three-dimensional imaging of the normal retina and optic nerve head were performed. The ultrahigh imaging speed reduced motion artifacts and improved the ability to visualize data sets en face. The nerve fiber layer and capillary vessel network can be visualized via en face projection of reflectance from specific retinal layers. The en face view of optic nerve head can be used to visualize the lamina cribrosa. The 1060 nm wavelength improved the imaging depth and enhanced the visualization of deeper retinal tissues such as the choroid and optic nerve head.
Swept source / Fourier domain OCT enables imaging 5 to 10x faster than commercial spectral / Fourier domain OCT instrument. Imaging at 250,000 axial scans per second reduces motion artifacts, enables acquisition of larger data sets and improves en face visualization methods. Imaging at longer wavelengths of 1060 nm improves image penetration depths.
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