April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Ultrahigh Speed Optical Coherence Tomography Imaging of Human Retina Using Swept Source / Fourier Domain OCT
Y. Chen; J. J. Liu; B. Potsaid; V. J. Srinivasan; J. S. Schuman; J. S. Duker; J. G. Fujimoto
Author Affiliations & Notes
  • Y. Chen
    Dept. of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts
  • J. J. Liu
    Dept. of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • B. Potsaid
    Advanced Imaging Group, Thorlabs Inc., Newton, New Jersey
  • V. J. Srinivasan
    Dept. of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • J. S. Schuman
    Dept. of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh, Pittsburgh, Massachusetts
  • J. S. Duker
    New England Eye Center, Tufts Medical Center, Boston, Massachusetts
  • J. G. Fujimoto
    Dept. of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts
  • Footnotes
    Commercial Relationships  Y. Chen, None; J.J. Liu, None; B. Potsaid, None; V.J. Srinivasan, None; J.S. Schuman, Alcon; Allergan; Carl Zeiss Meditec, Inc.; Merck; Heidelberg Engineering;Optovue, F; Carl ZeissMeditec, Inc., P; Alcon; Allergan; Carl Zeiss Meditec, Inc.;, R; J.S. Duker, Optovue, F; J.G. Fujimoto, Optovue, F; Carl Zeiss Meditec, Inc., P.
  • Footnotes
    Support  NIH R01-EY11289-21, NIH R01-EY13178-07, NIH R01-CA75289-11, NSF BES-0522845; AFSOR FA9550-07-1-0014 and MFEL FA9550-07-1-0101
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4776. doi:
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      Y. Chen, J. J. Liu, B. Potsaid, V. J. Srinivasan, J. S. Schuman, J. S. Duker, J. G. Fujimoto; Ultrahigh Speed Optical Coherence Tomography Imaging of Human Retina Using Swept Source / Fourier Domain OCT. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4776.

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Abstract

Purpose: : To demonstrate swept source / Fourier domain technology for ultrahigh speed OCT imaging of the retina and optic disc at 250,000 axial scans per second. To investigate imaging factors such as contrast and penetration depth using an alternative 1060 nm central wavelength. To study the improved visualization of the retina, choroid, and optic nerve with reduced motion artifacts by ultrahigh scanning speed enabled by swept source / Fourier domain OCT .

Methods: : A swept laser operating at 1060 nm central wavelength was developed using Fourier domain modelocking. A swept source / Fourier domain OCT retinal imaging system operating at 250,000 axial scans per second with ~10 um axial resolution was built using this novel laser. Imaging of the retina, choroid, and optic nerve was performed using dense raster scanning. Data processing methods were implemented to generate different views based on the 3D-OCT data sets.

Results: : High-definition and three-dimensional imaging of the normal retina and optic nerve head were performed. The ultrahigh imaging speed reduced motion artifacts and improved the ability to visualize data sets en face. The nerve fiber layer and capillary vessel network can be visualized via en face projection of reflectance from specific retinal layers. The en face view of optic nerve head can be used to visualize the lamina cribrosa. The 1060 nm wavelength improved the imaging depth and enhanced the visualization of deeper retinal tissues such as the choroid and optic nerve head.

Conclusions: : Swept source / Fourier domain OCT enables imaging 5 to 10x faster than commercial spectral / Fourier domain OCT instrument. Imaging at 250,000 axial scans per second reduces motion artifacts, enables acquisition of larger data sets and improves en face visualization methods. Imaging at longer wavelengths of 1060 nm improves image penetration depths.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • image processing • retina 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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