April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
The Role of Ethnicity on the Retinal Nerve Fiber Layer and Optic Disc Area Measured With Fourier Domain Optical Coherence Tomography
Author Affiliations & Notes
  • M. J. Sinai
    Clinical Affairs, Optovue, Inc, Carlsbad, California
  • D. F. Garway-Heath
    NIHR BMRC for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • M. Fingeret
    VA NY Health Care System, New York, New York
  • R. Varma
    Ophthalmology, Doheny Eye Institute, Los Angeles, California
  • J. M. Liebmann
    Ophthalmology, Manhattan Eye and Ear Throat Hospital, New York, New York
  • D. S. Greenfield
    Ophthalmology, Bascom Palmer Eye Institute, Palm Beach Gardens, Florida
  • C. A. Girkin
    Opthalmology, University of Alabama Birmingham, Birmingham, Alabama
  • J. S. Schuman
    Ophthalmology,, Ophthalmology and Visual Science Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania
  • Footnotes
    Commercial Relationships  M.J. Sinai, Optovue, Inc., E; D.F. Garway-Heath, Heidelberg Engineering, F; Optovue, F; Carl Zeiss Meditec, C; Carl Zeiss Meditec, R; Carl Zeiss Meditec, F; M. Fingeret, None; R. Varma, Optovue, F; J.M. Liebmann, None; D.S. Greenfield, None; C.A. Girkin, None; J.S. Schuman, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4785. doi:
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      M. J. Sinai, D. F. Garway-Heath, M. Fingeret, R. Varma, J. M. Liebmann, D. S. Greenfield, C. A. Girkin, J. S. Schuman; The Role of Ethnicity on the Retinal Nerve Fiber Layer and Optic Disc Area Measured With Fourier Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4785.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To determine if there are ethnic differences in RNFL thickness and optic disc area in healthy eyes.

Methods: : 861 healthy eyes from 15 clinics around the world were enrolled. All participants underwent a full eye examination, standard achromatic perimetry (SITA- standard 24-2) and scanning with the RTVue, a Fourier-domain optical coherence tomography (FD-OCT) device manufactured by Optovue, Inc., Fremont CA. All participants had normal visual fields (GHT within normal limits and PSD > 5%) and intraocular pressure < 22 mm Hg. A general linear model using ethnicity, age, and optic disc area was used to determine possible RNFL differences.

Results: : Descriptive statistics for the variables (mean +/- standard deviation) are shown in the table below for the various ethnic groups. Significant ethnic differences were found for average RNFL thickness, taking into account effects of age and optic disc size (P<0.001). Significant ethnic differences were also found for optic disc area (p< .001). No significant differences were found for the correlation of RNFL thickness and age between ethnic groups (similar slopes), or for the correlation of RNFL thickness and optic disc are between ethnic groups (similar slopes).

Conclusions: : Significant effects for ethnicity on RNFL thickness were found, even taking into account age and optic disc size. This finding suggests ethnic specific normative databases may improve clinical efficacy of Fourier Domain OCT.

Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • optic nerve 

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