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A. Roller, H. C. Boldt, V. B. Mahajan, M. D. Abramoff, S. R. Russell, J. C. Folk; Progression of Age-Related Macular Degeneration After Vitrectomy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4922.
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To determine whether vitrectomy might reduce the long-term progression of age-related macular degeneration (AMD).
Retrospective case-control series. The charts and photographs were reviewed of subjects with AREDS category 3 AMD who underwent vitrectomy surgery for an epiretinal membrane or macular hole. Subjects were excluded if they had a vitrectomy in both eyes, previous choroidal neovascularization (CNV) in either eye, less than 2 years of follow-up, retinal detachment, diabetic retinopathy, angioid streaks, high myopia, vascular occlusions, or extensive macular scarring. The fellow, non-vitrectomized eye was used as a case-control. Three vitreoretinal specialists evaluated fundus photographs of all eyes in a masked fashion. Primary endpoints for progression included onset or enlargement of geographic atrophy and development of choroidal neovascularization.
Twenty-two patients who met the entry criteria were included. The average follow up interval was 5.6 years with a range of 2-15 years. CNV developed four control eyes and in two vitrectomy eyes. There was no significant difference in the onset or enlargement of geographic atrophy between the groups of eyes.
Our results suggest that vitrectomy does not alter the progression of geographic atrophy in AMD. Additional subjects are needed to determine whether vitrectomy might reduce the risk of CNV.
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