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A. Zhao; Effect of Topical Bevacizumab (Avastin) on Experimental Corneal Neovascularization in Mice. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4950.
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To evaluate the effect of topical bevacizumab(Avastin) on experimental corneal neovascularization in mice.
Thirty eyes of 30 Balb/c mices were chemically cauterized by applying a filter paper of 2mm in diameter soaked of 1 mol/L NaOH solution to the center of cornea for 40s.All animals(n=30)were randomly assigned to five groups, respectively topical application of 1mg/ml, 3mg/ml and 5mg/ml Avastin eye drops on mices’cornea twice per day. 1mg/ml Dexamethasone sodium phosphate eye drops as the positive control, and NS solvent as the negative control twice per day. All animals were killed on the 14th day. The percentages of neovascularization on the surface of the cornea were measured in terms of pixels on digital photographs.
The area of neovascularization at the cornea surface was (37.11±3.17)% in group A, (29.75±3.56)% in group B, (18.76±2.55)% in group C, (20.91±2.75)% in group D and (41.65±2.11)% in group E. The average number of neovascular vessels at group C was significantly reduced in comparison with other groups(P<0.001).
topical bevacizumab (Avastin) decreases the extent of chemically induced corneal neovascularization in mices.
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