April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Scanning Laser Polarimetry Is Predictive of Development of Glaucomatous Visual Field Defects in Glaucoma Suspects
D. Chao; L. M. Alencar; R. N. Weinreb; L. M. Zangwill; C. Bowd; P. A. Sample; F. A. Medeiros
Author Affiliations & Notes
  • D. Chao
    School of Medicine,
    University of California San Diego, La Jolla, California
  • L. M. Alencar
    Ophthalmology,
    University of California San Diego, La Jolla, California
    Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
  • R. N. Weinreb
    Ophthalmology,
    University of California San Diego, La Jolla, California
  • L. M. Zangwill
    Ophthalmology,
    University of California San Diego, La Jolla, California
  • C. Bowd
    Ophthalmology,
    University of California San Diego, La Jolla, California
  • P. A. Sample
    Ophthalmology,
    University of California San Diego, La Jolla, California
  • F. A. Medeiros
    Ophthalmology,
    University of California San Diego, La Jolla, California
    Ophthalmology, University of Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  D. Chao, None; L.M. Alencar, None; R.N. Weinreb, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Paradigm, F; Topcon, F; Carl Zeiss Meditec, C; L.M. Zangwill, Carl Zeiss Meditec, F; Heidelberg Engineering, F; Nidek, F; Optovue, F; C. Bowd, Lace Elettronica, F; P.A. Sample, Carl Zeiss Meditec, F; Welch-Allyn, F; Haag-Streit, F; F.A. Medeiros, Pfizer, F; Alcon, F; Carl Zeiss Meditec, F; Pfizer, C; Alcon, C; Allergan, C; Carl Zeiss Meditec, C; Pfizer, R; Alcon, R; Allergan, R; Carl Zeiss Meditec, R; Reichert Inc., R.
  • Footnotes
    Support  NEI EY08208 (PAS), NEI EY11008 (LMZ), and participant retention incentive grants in the form of glaucoma medication at no cost from Alcon Laboratories Inc, Allergan, Pfizer Inc, and Santen Inc.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4394. doi:
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      D. Chao, L. M. Alencar, R. N. Weinreb, L. M. Zangwill, C. Bowd, P. A. Sample, F. A. Medeiros; Scanning Laser Polarimetry Is Predictive of Development of Glaucomatous Visual Field Defects in Glaucoma Suspects. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4394.

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Abstract

Purpose: : To determine whether Scanning Laser Polarimetry (GDx VCC) results may predict the development of visual field defects or progressive optic disc deterioration in glaucoma suspects.

Methods: : This was an observational cohort study that included 270 eyes of 169 patients recruited from the longitudinal Diagnostic Innovations in Glaucoma Study (DIGS). All eligible eyes had a reliable standard automated perimetry (SAP) visual field and optic disc stereophotograph within one year of the baseline GDx. Glaucoma suspects were defined as those with normal SAP at baseline but elevated IOP (>21mmHg) and/or suspicious optic disc appearance. Glaucomatous conversion was defined as the development of 3 consecutive abnormal visual fields (defined as glaucoma hemifield test (GHT) outside normal limits and/or pattern standard deviation (PSD) with P<0.05) and/or progressive optic disc change determined by masked assessment of optic disc stereophotographs. Cox regression models were used to assess the association between baseline GDx measurements and development of glaucoma. Multivariate models were constructed to determine the predictive ability of GDx after adjusting for age, IOP, central corneal thickness (CCT) and PSD.

Results: : Twenty-nine (11%) eyes developed glaucomatous optic disc deterioration and/or visual field defects during an average follow-up time of 4.3 ± 1.1 years. In univariate analysis, all GDx parameters were significantly associated with conversion. The hazard ratios (95% CI) for NFI, average thickness, superior thickness and inferior thickness were 1.48 (1.20 to 1.83) per 10 units larger, 3.30 (2.00 to 5.46) per 10µm thinner, 2.19 (1.50 to 3.20) per 10µm thinner, and 2.02 (1.40 to 2.92) per 10µm thinner, respectively. In the multivariate models, adjusting for CCT, PSD, IOP and age, the hazard ratios were 1.36 (1.06 to 1.75), 2.09 (1.24 to 3.50), 1.68 (1.18 to 2.40) and 1.44 (0.96 to 2.17), respectively.

Keywords: imaging/image analysis: clinical • optic disc 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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