April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Myocardial Infarction and Cerebrovascular Accident in Patients With Diabetic Macular Edema
Author Affiliations & Notes
  • A. E. Fung
    Ophthalmology, California Pacific Medical Center, San Francisco, California
  • R. S. Apte
    Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri
  • B.-A. Nguyen-Khoa
    The Degge Group, Ltd, Arlington, Virginia
  • E. L. Goehring
    The Degge Group, Ltd, Arlington, Virginia
  • W. Werther
    Genentech Inc., South San Francisco, California
  • J. K. Jones
    The Degge Group, Ltd, Arlington, Virginia
  • Footnotes
    Commercial Relationships  A.E. Fung, Genentech, F; R.S. Apte, Genentech, F; Genentech, C; Genentech, R; B.-A. Nguyen-Khoa, Genentech, F; E.L. Goehring, Genentech, F; W. Werther, Genentech, E; J.K. Jones, Genentech, F.
  • Footnotes
    Support  Genentech
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 4423. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      A. E. Fung, R. S. Apte, B.-A. Nguyen-Khoa, E. L. Goehring, W. Werther, J. K. Jones; Myocardial Infarction and Cerebrovascular Accident in Patients With Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2009;50(13):4423.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : To compare the incidence rates of hospitalized myocardial infarctions (MI) and cerebrovascular accidents (CVA) in subjects with diabetic macular edema (DME) to those with diabetes but no retinal diseases.

Methods: : A retrospective healthcare claims database cohort study was performed in DME subjects and diabetes controls matched for age and gender. The Ingenix LabRx Database(TM) was used to identify subjects and outcomes during the study period from January 1, 2002 to December 31, 2005. International Classification of Diseases 9th revision (ICD-9) codes were used to identify DME subjects, diabetes controls, MI, CVA, and covariates. Incidence of hospitalized MI and CVA events and adjusted rate ratios were calculated. Rate ratios were adjusted for history of MI, CVA, congestive heart failure, cardiac arrhythmia, other cerebrovascular diseases, hypertension, hyperlipidemia, coronary artery disease, angina, and use of anticoagulant or antiplatelet drugs.

Results: : In 3,519 DME subjects and 10,557 diabetes controls, the event rate of MI was 1.97/100 person years (PY) in DME, and 0.69/100 PY in controls. The adjusted rate ratio for MI was 2.53 (95% CI: 1.85-3.46, P<.001) for DME vs diabetes controls. The event rate of CVA was 1.38/100 PY in DME subjects, and 0.54/100 PY in controls. The adjusted rate ratio for CVA was 1.98 (95% CI: 1.39-2.84, P<.001).

Conclusions: : Event rates of MI or CVA were significantly higher in subjects with DME than in diabetes controls. This study provides quantitative data on the relationship between DME and cardiovascular outcomes.

Keywords: diabetic retinopathy • clinical (human) or epidemiologic studies: prevalence/incidence • edema 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.