April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Short-wavelength Fundus Autofluorescence and Near-infrared Reflectance of Choroidal Tumors
Author Affiliations & Notes
  • L. Amselem
    Ophthalmology, Hospital 2 de Mayo, Barcelona, Spain
  • J. S. Pulido
    Ophthalmology, Mayo Clinic, Rochester, Minnesota
  • K. Gündüz
    Ophthalmology, Ankara University School of Medicine, Ankara, Turkey
  • J. García-Arumí
    Ophthalmology, Hospital Vall
  • J. Monés
    Ophthalmology, Institut de la Màcula i de la Retina, Barcelona, Spain
  • F. Huste
    Ophthalmology, Hospital 2 de Mayo, Barcelona, Spain
  • R. Abreu
    Ophthalmology, Hospital Universitario la Candelaria, Tenerife, Spain
  • M. J. Romero
    Ophthalmology, Hospital Mutua de Terrassa, Terrassa, Spain
  • Footnotes
    Commercial Relationships  L. Amselem, None; J.S. Pulido, None; K. Gündüz, None; J. García-Arumí, None; J. Monés, None; F. Huste, None; R. Abreu, None; M.J. Romero, None.
  • Footnotes
    Support  Unrestricted Grant from Research to Prevent Blindness Inc. NY, USA.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5232. doi:
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    • Get Citation

      L. Amselem, J. S. Pulido, K. Gündüz, J. García-Arumí, J. Monés, F. Huste, R. Abreu, M. J. Romero; Short-wavelength Fundus Autofluorescence and Near-infrared Reflectance of Choroidal Tumors. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5232.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Choroidal tumours are associated with several degenerative changes in the overlying tissues. These changes have been called "Tumour-Associated Retinal Pigment Epitheliopathy" (TARPE). The presence of lipofuscin (orange pigment) is a sign of retinal pigment epithelial distress. The purpose of this study is to describe short-wavelength fundus autofluorescence (SW-FAF) and near-infrared reflectance (IRR) findings in choroidal tumors.

Methods: : Retrospective chart review of 44 consecutive patients with choroidal tumors who underwent SW-FAF and IRR photography. The correlation between SW-FAF and IRR patterns and foci of orange pigment, hyperpigmentation, drusen, fibrous metaplasia and subretinal fluid, was evaluated.

Results: : The mean patient age was 65. Twenty-nine patients had a choroidal melanoma, 9 patients had choroidal metastasis, and 6 patients had a choroidal hemangioma. All tumors showed many foci of increased SW-FAF and/or increased IRR. Orange pigment displayed the brightest SW-FAF and was hyperreflective in IRR imaging. IRR imaging highlighted the presence of condensed clumps of orange pigment, presenting a good correlation with SW-FAF imaging, but barely detected diffuse fine lipofuscin. Related RPE hyperplasia and atrophy were isoreflective with the normal fundus, showing low correlation with SW-FAF, where they appeared mainly hypofluorescent. Lipid exudates and drusen were hyperreflective in IRR imaging and difficult to distinguish from the orange pigment, creating a "confusion factor". Fibrous metaplasia was mainly hyperreflective while it was hypofluorescent in SW-FAF imaging. Subretinal fluid was barely visible in IRR imaging, while SW-FAF imaging highlighted its presence. The top of dome-shaped surfaces in the fundus were usually hyperreflective, creating an artifact that didn't exist in SW-FAF imaging.

Keywords: oncology • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • ipofuscin 

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