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A. P. Ciardella, C. Veronese, F. Pichi, F. Borri, S. Guidelli Guidi, C. Torrazza, M. Morara; Spectral-Domain Optical Coherence Tomography and Autofluorescence Findings in Retinal Astrocytic Hamartomas. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5236.
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© ARVO (1962-2015); The Authors (2016-present)
To describe the features of retinal astrocytic hamartomas (RAHs) in Tuberous Sclerosis (TS) using Spectral-Domain Optical Coherence Tomography (SD-OCT) and Autofluorescence (AF)
Features of SD-OCT and AF (HRA SPECTRALIS, Heidelberg Engineering) images of 14 patients affected by TS with RAHs.
There were 14 Caucasian patients with TS (27 eyes), 7 females and 7 males, the mean age was 25.5 years (SD 5.32, range 19-32). The localization of the RHAs was 45.5% superotemporal, 18.2% inferotemporal, 27.3% peripapillary, 9% paramacular. 63.63% of the RHAs showed hypoautofluorescence and 46, 37% showed hyperautofluorescence consistent with intratumoral calcification. By SD-OCT 4 types of RHAs were identified: Type I RHAs (38%) were mildly elevated inner retinal lesions without retinal traction, with a gradual gently sloping transition from a normal retina into the tumours, Type II RHAs (38%) demonstrated retinal traction and retinal disorganization limited to inner retina, Type III RHAs (20%) showed dome shaped, moth-eaten appearance with intralesional calcifications, Type IV RHAs (6%) showed a dome shaped lesion, with an optically empty, cavitary, intralesional space.
RHAs showed characteristics features on AF and SD-OCT. With AF it was possible to classify the tumours in hypoautoflourescent lesions, consistent with Type I and II, and hyperautofluorecent lesions as a result of calcification typical of Type III. SD-OCT showed gradual transition from a normal retina into an optically hyper-reflective mass with retinal disorganisation, characteristic moth-eaten spaces and posterior shadowing. It has also been recognized a new particularly feature of RHAs characterized by a cavitary space within the astrocytic hamartoma (Type IV).
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