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D. E. Pelayes, M. Folgar, L. Racca, C. H. Pastore, J. O. Zarate; Pleomorphic Xanthoastrocytoma of the Retina a Divergent Tumor. Immunohistochemical Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5240.
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© ARVO (1962-2015); The Authors (2016-present)
We report two new cases and review the literature of pleomorphic xanthoastrocytomas of the retina with inmunohistochemical study
The immunoreactivity to CD68 (monoclonal Clone KP1), macrophage (monoclonal Clone HAM 56) and antibodies to glial fibrillary acidic protein (GFAP;monoclonal) was tested in tumor cells. The cases contained cells immunoreactive for glial fibrillary acidic protein and some cells with macrophage and CD68.
Were found many large pleomorphic cells contained vesicular and enlarged nuclei with a homogeneous eosinophilic cytoplasm, prominent nucleoli, and calcium deposits. Some cells had a markedly swollen lipidized cytoplasm, whereas others were spindle-shaped and contained multiple nuclei. The large pleomorphic and swollen cells have in part, a divergent differentiation with glial and macrophagic marker cells.
The findings suggest that pleomorphic xantoastrcytomas have an astroglial and histiocytic lineage and are similar to pleomorphic xanthoastrocytomas of the CNS brain and spinal cord. After 5 years both are free of disease.
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