Abstract
Purpose: :
We report two new cases and review the literature of pleomorphic xanthoastrocytomas of the retina with inmunohistochemical study
Methods: :
The immunoreactivity to CD68 (monoclonal Clone KP1), macrophage (monoclonal Clone HAM 56) and antibodies to glial fibrillary acidic protein (GFAP;monoclonal) was tested in tumor cells. The cases contained cells immunoreactive for glial fibrillary acidic protein and some cells with macrophage and CD68.
Results: :
Were found many large pleomorphic cells contained vesicular and enlarged nuclei with a homogeneous eosinophilic cytoplasm, prominent nucleoli, and calcium deposits. Some cells had a markedly swollen lipidized cytoplasm, whereas others were spindle-shaped and contained multiple nuclei. The large pleomorphic and swollen cells have in part, a divergent differentiation with glial and macrophagic marker cells.
Conclusions: :
The findings suggest that pleomorphic xantoastrcytomas have an astroglial and histiocytic lineage and are similar to pleomorphic xanthoastrocytomas of the CNS brain and spinal cord. After 5 years both are free of disease.
Keywords: oncology • microscopy: light/fluorescence/immunohistochemistry • pathology: human