Spectral OCT vs. Stratus OCT to Evaluate Macular Morphology in Wet Age Related Macular Degeneration

Abstract

Purpose: : to compare the agreement between Spectral-domain OCT and Stratus-domain OCT to evaluate macular morphology in wet age-related macular degeneration (AMD).

Methods: : seventy-seven randomly chosen consecutive eyes of 77 patients with wet age-related macular degeneration were involved. Inclusion criteria: patients with primary or recurring subfoveal CNV secondary to AMD, including those with predominantly classic, minimally classic or occult lesions with no classic component. Exclusion criteria: other types of CNV, other concomitant macular diseases. All patients underwent OCT examination using two OCT devices: Zeiss Stratus OCT 3 and Opko OTI SLO/OCT. During every examination we evaluated the presence of pigment epithelium detachment, sensory retina serous detachment, cystoid macular edema, epiretinal membrane, inner limiting membrane thickening and exudates. Levels of agreement between the two evaluations were quantified by Kappa measure of agreement.

Results: : presence of pigment epithelium detachment: kappa value 0.15; presence of sensory retina serous detachment: kappa value 0.61; presence of cystoids macular edema: kappa value 0.18; presence of epiretinal membrane: kappa value 0.41; presence of inner limiting membrane thickening: kappa value 0.02; presence of exudates: kappa value 0.06.

Conclusions: : agreement in the evaluation of macular morphology between Spectral-domain OCT and Stratus-domain OCT is strongly dependent on the parameter measured. Substantial agreement was found in the evaluation of sensory retina serous detachment; moderate agreement was found in the evaluation of epiretinal membrane; slight agreement was found in the evaluation of cystoid macular edema, pigment epithelium detachment, exudates and inner limiting membrane thickening.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • age-related macular degeneration • macula/fovea