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M. G. Cereda, B. Parolini, E. Bellesini, G. Pertile; Oct Spectral-Domain Images of Rpe-Choroid Graft in Patient With Exudative Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5257.
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To study Graft perfusion using Fluorescein (FA) and Indocyanin Green (ICGA) Angiography and dynamic-angiography with high-resolution HRA Spectralis (Heidelberg Engeneering) after the translocation of an autolougus patch of choroid, choriochapillars and Retinal Pigmented epithelium(APCCR) and evaluate the morfology of the patch with spectral-domain OCT in patients with exudative age-related macular degeneration (AMD).
Retrospective Observetional case series of 16 patients with AMD after an APCCR transplantation who underwent FA and ICGA angiography and dynamic-angiography of the first 30 seconds of vascular perfusion at one week, two week, one month, three months, six months and one year after surgery. Revascularization of the patch was assessed for the presence of an early fluorescence in FA and for perfusion of choroidal vessels in ICGA. 7 of this patients underwent high-resolution OCT Spectralis and the characteristics of the retina and of the APCCR underneath were recorded.
Early fluorescence in FA and filling of choroidal vessel of the patch in ICGA were present in 15 of the 16 patients. The medium time of evidence of revascularization after surgery was 25,7 days (SD ± 20) range: 7-90 days. In 14 patients signs of perfusion were manteined till the end of follow-up. In one patient revascularization occurred after one months and disappeared after three months. In 7 of the 14 patients was evident a feeder-vessel in ICGA starting from perifery of the graft. On OCT the shape of the patch: flat or dome-shaped, the folds of RPE due to graft contraction, the well defined opened choroidal-vessels, the presence of sub-retinal fluid and cystoid edema, the morfology of the retina layers were noted.
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