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M. E. Clark, G. McGwin, Jr., C. A. Girkin, B. Ozaydin, D. Neely, J. O. Mason, III, M. F. White, Jr., R. Feist, M. Thomley, C. Owsley; Association Between Retinal Thickness as Measured by High Definition, Spectral Domain OCT and Dark Adaptation in Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5258.
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This study explored whether there is an association between retinal thickness and dark adaptation in older adults with varying degrees of age-related macular degeneration or normal retinal health.
Participants were recruited through the department's retina and comprehensive care services. After pupillary dilation, dark adaptation (recovery of light sensitivity) was measured following an intense flash for a 1.7 degree diameter, 500nm target positioned at 5 degrees on the inferior vertical meridian. Retinal thickness was estimated using the Cirrus HD spectral domain OCT and its macular cube 512x128 protocol and research browser. Stereoscopic color 30-degree fundus photographs were taken with a FF450Plus camera and evaluated using the AREDS severity scale for AMD by trained graders masked to patient clinical and functional characteristics.
The sample consisted of 80 participants (M age 77 years, SD 8). Cone- and rod-mediated parameters of dark adaptation, signifying the rate of recovery of visual sensitivity over time, were estimated using a piecewise, nonlinear regression model. The slope representing the second component of rod-mediated dark adaptation was associated with retinal thickness in the regions within and adjacent to the psychophysically tested area (p < .05); those participants with thicker retina were more likely to have faster rates of rod-mediated dark adaptation.
These results imply that there may be structure-function relationships in AMD that can be documented through the use of HD spectral domain OCT and dark adaptometry, an area deserving of further investigation.
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