Abstract
Purpose: :
To correlate the morphologic characteristics of choroidal neovascular lesions (CNV) in age-related macular degeneration (AMD) using raster scanning high-definition optical coherence tomography (HD-OCT) and conventional fluorescein angiography (FA).
Methods: :
In these comparative case series, 37 consecutive patients with classic, minimally classic or occult CNV were included. Ten age-matched healthy individuals and 13 patients with early AMD served as controls. HD-OCT imaging (TOPCON) and FA (HRA2) were performed following a complete standardized ophthalmologic examination. A point-to-point correlation between HD-OCT and FA images was performed using the built-in software. Early and late FA images at defined locations were correlated with OCT measurements, including 3D maps, 2D single scans, a thickness linear graph and the 3D retinal pigment epithelium (RPE) segmentation.
Results: :
Using HD-OCT imaging to delineate the lesion morphology, early AMD was detected as normal foveal contour and minimal alterations of the macular area, classic CNV as a well-defined lesion with steep margins and a crater-like configuration, occult CNV as an illdefined, flat lesion with convex surface and minimally classic CNV was characterized by its classic and occult components. FA-OCT overlay images provided a significant correlation between FA patterns and OCT features such as retinal thickness (RT) values.
Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical