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S. Sacu, P. Malamos, M. Georgopoulos, C. Pruente, U. Schmidt-Erfurth; Correlation of High-Definition Optical Coherence Tomography and Fluorescein Angiography Imaging in Neovascular Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5260.
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To correlate the morphologic characteristics of choroidal neovascular lesions (CNV) in age-related macular degeneration (AMD) using raster scanning high-definition optical coherence tomography (HD-OCT) and conventional fluorescein angiography (FA).
In these comparative case series, 37 consecutive patients with classic, minimally classic or occult CNV were included. Ten age-matched healthy individuals and 13 patients with early AMD served as controls. HD-OCT imaging (TOPCON) and FA (HRA2) were performed following a complete standardized ophthalmologic examination. A point-to-point correlation between HD-OCT and FA images was performed using the built-in software. Early and late FA images at defined locations were correlated with OCT measurements, including 3D maps, 2D single scans, a thickness linear graph and the 3D retinal pigment epithelium (RPE) segmentation.
Using HD-OCT imaging to delineate the lesion morphology, early AMD was detected as normal foveal contour and minimal alterations of the macular area, classic CNV as a well-defined lesion with steep margins and a crater-like configuration, occult CNV as an illdefined, flat lesion with convex surface and minimally classic CNV was characterized by its classic and occult components. FA-OCT overlay images provided a significant correlation between FA patterns and OCT features such as retinal thickness (RT) values.
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