April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Optical Coherence Tomography (OCT) Macula Thickness (MT) in Subjects with Early Age-Related Macular Degeneration (AMD) or Geographic Atrophy (GA)
T. Pappas; A. Koskosas; X. Yin; E. Anastasopoulos; P. Founti; E. Amoiridou; A. Antoniadis; V. Kilintzis; U. Chakravarthy; F. Topouzis
Author Affiliations & Notes
  • T. Pappas
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • A. Koskosas
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • X. Yin
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • E. Anastasopoulos
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • P. Founti
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • E. Amoiridou
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • A. Antoniadis
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • V. Kilintzis
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • U. Chakravarthy
    Centre for Vision Science, Queens University of Belfast, Belfast, United Kingdom
  • F. Topouzis
    A' Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships  T. Pappas, None; A. Koskosas, None; X. Yin, None; E. Anastasopoulos, None; P. Founti, None; E. Amoiridou, None; A. Antoniadis, None; V. Kilintzis, None; U. Chakravarthy, None; F. Topouzis, None.
  • Footnotes
    Support  The Project is co-funded by the European Union – European Social Fund and National Resources - (EPEAEK-II)
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5265. doi:
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      T. Pappas, A. Koskosas, X. Yin, E. Anastasopoulos, P. Founti, E. Amoiridou, A. Antoniadis, V. Kilintzis, U. Chakravarthy, F. Topouzis; Optical Coherence Tomography (OCT) Macula Thickness (MT) in Subjects with Early Age-Related Macular Degeneration (AMD) or Geographic Atrophy (GA). Invest. Ophthalmol. Vis. Sci. 2009;50(13):5265.

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Abstract

Purpose: : To evaluate and to compare OCT MT in subjects with different stages of early AMD, GA and subjects over 60 years of age without any signs of AMD (controls).

Methods: : In a study evaluating phenotypes of AMD, 77 consecutive participants with early AMD (grade 1-3) or GA underwent an ophthalmic examination and OCT imaging of the macula (MT map protocol, Stratus OCT). Also, 100 controls over 60 years of age randomly selected from a population-based study were included in the study. MT measurements were assessed for the nine divided sectors as provided by the OCT and were compared among the groups. T-test between two subgroups or ANOVA (analysis of variance) across more than two subgroups was used to compare the mean of continuous data with normal distribution and homogeneous variance across subgroups. Pairwise comparison with Bonferroni correction of the P-values was applied when there was significant difference across more than two subgroups. ANOCOVA (analysis of covariance) was used while adjusting for age.

Results: : After adjusting for age, inner inferior (OIIS), inner nasal (OINS), inner superior (OISS), inner temporal (OITS) and outer nasal sector (OONS) were significantly different among early AMD grade 1 to 3 and GA. In pairwise comparison, OIIS in GA was lower than that in grade 2 (P=0.02), OINS was lower than that in grade 2 and 3 (P=0.003 and P=0.007 respectively), OISS was lower than that in grade1, 2 and 3 (P=0.05, P=0.001 and P=0.001 respectively) and OITS was lower than that in grade 1, 2 and 3 (P=0.03, P=0.001 and P=0.006 respectively). OIIS, OINS, OISS, OITS, OONS and outer superior sector (OOSS) were significantly lower in GA compared to controls. No significant differences in any of the OCT variables were found among grades of early AMD or among early AMD and controls.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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