Purchase this article with an account.
T. Pappas, A. Koskosas, X. Yin, E. Anastasopoulos, P. Founti, E. Amoiridou, A. Antoniadis, V. Kilintzis, U. Chakravarthy, F. Topouzis; Optical Coherence Tomography (OCT) Macula Thickness (MT) in Subjects with Early Age-Related Macular Degeneration (AMD) or Geographic Atrophy (GA). Invest. Ophthalmol. Vis. Sci. 2009;50(13):5265.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate and to compare OCT MT in subjects with different stages of early AMD, GA and subjects over 60 years of age without any signs of AMD (controls).
In a study evaluating phenotypes of AMD, 77 consecutive participants with early AMD (grade 1-3) or GA underwent an ophthalmic examination and OCT imaging of the macula (MT map protocol, Stratus OCT). Also, 100 controls over 60 years of age randomly selected from a population-based study were included in the study. MT measurements were assessed for the nine divided sectors as provided by the OCT and were compared among the groups. T-test between two subgroups or ANOVA (analysis of variance) across more than two subgroups was used to compare the mean of continuous data with normal distribution and homogeneous variance across subgroups. Pairwise comparison with Bonferroni correction of the P-values was applied when there was significant difference across more than two subgroups. ANOCOVA (analysis of covariance) was used while adjusting for age.
After adjusting for age, inner inferior (OIIS), inner nasal (OINS), inner superior (OISS), inner temporal (OITS) and outer nasal sector (OONS) were significantly different among early AMD grade 1 to 3 and GA. In pairwise comparison, OIIS in GA was lower than that in grade 2 (P=0.02), OINS was lower than that in grade 2 and 3 (P=0.003 and P=0.007 respectively), OISS was lower than that in grade1, 2 and 3 (P=0.05, P=0.001 and P=0.001 respectively) and OITS was lower than that in grade 1, 2 and 3 (P=0.03, P=0.001 and P=0.006 respectively). OIIS, OINS, OISS, OITS, OONS and outer superior sector (OOSS) were significantly lower in GA compared to controls. No significant differences in any of the OCT variables were found among grades of early AMD or among early AMD and controls.
This PDF is available to Subscribers Only