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F. Sulzbacher, C. Kiss, G. Mylonas, M. Munk, M. Baratsits, U. Schmidt-Erfurth; Extent of Leakage Activity and Lesion Size of Choroidal Neovascularization in Age-Related Macular Degeneration - A Juxtaposition of Spectral Domain Optical Coherence Tomography and Indocyanine Green Angiography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5267.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the imaging-modality-dependant characteristics of choroidal neovascular lesions secondary to age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SDOCT) and indocyanine green angiography (ICGA).
Sixteen eyes showing untreated neovascular AMD (9 classic, 7 occult) were examined by SDOCT and ICGA.The greatest linear dimension (GLD) of the neovascular lesion and of the area of leakage was assessed both in the central scan of SDOCT (showing the foveolar depression) and at the 3 minute image of the ICGA. To ensure correct measurement, the ICGA image was manually overlaid to the SDOCT image using virtualDub (Ver.1.8.6) and Paint.NET(Ver. 3.36) software. The GLD was measured using Image J software.OCT-Lesion diameter was defined as disruption of the retinal pigment epithelial band. Additionally, the extension of sub- or intraretinal fluid was measured in OCT and related to fluorescence patterns of the ICGA.
In classic CNV mean GLD of the hyperfluorescent area in ICGA was 1029 ± 656µm, while the mean GLD of the lesion in SDOCT was consistently larger at a mean of 1550 ± 940µm. Thereof, a mean ICGA/SDOCT ratio of 0.67 (range 0.45 to 0.89) could be calculated. The mean GLD of the area deviating from "normal" ICGA fundus fluorescence, i.e. the diameter of the hyper- and hypofluorescent areas was 2909 ± 1163µm, while the mean extension of retinal pathology (i.e. fluid and RPE disruption) in SDOCT was 3624 ± 1303µm. In this case an ICGA/SDOCT ratio of 0.80 (range 0.50 to 1.24) was noted. In occult CNV mean GLD was 3714 ± 1403µm in ICGA. In these cases the corresponding values in SDOCT were similar at 3699 ± 1451µm. The ICGA/SDOCT ratio in occult CNV cases was 1.0 (range 0,7 - 1,2).
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