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E. M. Hoffmann, J. Lamparter, S. Aliyeva, N. Pfeiffer; Standard Automated Perimetry versus Matrix Frequency Doubling Technology Perimetry in Patients With Ocular Hypertension and Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5289.
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To evaluate the relationship and agreement between standard automated perimetry (SAP) and Matrix frequency doubling technology (FDT) in patients with ocular hypertension and healthy subjects.
Fourty-five eyes of fourty-five ocular hypertensives and thirty eyes of thirty healthy control subjects were included in this prospective study. All subjects underwent complete ophthalmic examination, including slit-lamp biomicroscopy, intraocular pressure measurement, pachymetry measurement, and dilated fundus examination, and showed reliable visual field tests. One randomly selected eye of each participant was examined with SAP (Swedish Interactive Threshold Algorithm [SITA] Standard 24-2 test) and Matrix-FDT (24-2 threshold test), in random order. Mean deviation, pattern standard deviation, each visual field test location, and specific sectors of the visual field were compared between both techniques.
In both groups, mean deviation values of SAP and Matrix-FDT correlated significantly (r = 0.44 and 0.60, p-value < 0.005). Pattern standard deviation showed no significant correlation in healthy subjects but correlated significantly in patients (r = 0.47, p-value < 0.005). In the healthy subject group, a significant correlation between SAP and Matrix FDT was shown in the supero-temporal and infero-temporal sectors of the visual field (r = 0.46 and 0.37, p-value < 0.05). In patients, supero-temporal, supero-nasal and nasal sectors correlated significantly (r = 0.52, 0.61 and 0.35, p-values ≤ 0.02). The correlation pattern of individual visual field test locations appeared heterogenous in both groups.
In both the ocular hypertensive patients and healthy subjects SAP and Matrix-FDT correlate well. Further investigations should find out whether the missing corrrelation between both techniques in the temporal, infero-temporal and infero-nasal visual field sectors of OHT patients might be related to early retinal fiber layer damages in these regions of the disc and therefore could indicate probable conversion to glaucoma.
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