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S. E. Brown, S. E. Brodie, R. M. Fischer; A Comparison of Microperimetry Using the Spectral OCT/SLO With Humphrey Field Analysis. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5291.
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© ARVO (1962-2015); The Authors (2016-present)
Microperimetry has been shown to offer a potentially more sensitive measure of changes in macular function in patients with glaucoma as compared with Humphrey Field Analysis (HFA), the current gold standard in visual field examination. This can be attributed to the ability of microperimeters to track and correct for eye movement throughout the examination. In this retrospective study, we compared data from a new microperimeter, which is integrated with the Spectral OCT/SLO by Ophthalmic Technologies, Incorporated (OTI), with HFA examinations in patients with split fixation visual field defects.
Results of HFA and microperimetry examinations of thirty-one eyes were collected and analyzed. Inclusion criteria were prior 24-2 or 10-2 HFA examinations that displayed visual field defects that involved the macula (e.g., split fixation). HFA was performed using 10-2 threshold tests. Microperimetry was completed using the Spectral OCT/SLO and was nominally based on the same array of retinal locations as the Humphrey 10-2 protocol. The correlation between the two devices was evaluated using linear regression analysis.
Mean light thresholds with the HFA and microperimeter were 16.25±3.52 decibels (dB) (range, 0.00-34.00) and 9.04±1.55 dB (range, 0.00-20.00), respectively. Linear regression analysis revealed significant positive correlations between the Humphrey Field Analyzer and OTI's microperimeter for all of the 56 points on the macula. Thresholds in decibels on the microperimeter were 25 to 35 percent of the values for the same locations as reported by the HFA. Three-dimensional contour plots of the regression analyses demonstrated similar correlation coefficients and regression line slopes throughout the visual fields, with greater values in the peripheral visual field as compared to in the central regions.
The results demonstrated a strong correlation between microperimetry using the Spectral OCT/SLO and HFA. This validates the potential of OTI’s microperimeter to be employed in the management of patients with advanced glaucoma as well as to provide a more sensitive measure of changes in macular function over time due to its eye movement tracking capability. Further evaluation of this microperimeter’s ability to monitor changes in visual function in patients with glaucoma is warranted at this time.
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