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E. Lin, M. W. Dul, H. J. Wyatt, A. Hot; Diffuse Loss of Sensitivity in the Central 10 Degrees of Patients With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5297.
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There is evidence that, in glaucoma, diffuse loss of sensitivity occurs for the 24-2 test pattern (Henson et al, 1999). We have assessed the presence of diffuse loss of sensitivity within 10 degrees of fixation, using the 10-2 test pattern in a population of patients with glaucoma.
We tested 46 eyes of 46 subjects, 23 POAG patients with pattern visual loss within 10 degrees of fixation and 23 controls. Each POAG eye was matched with an age-similar control eye. All subjects were experienced with automated perimetry, had clear media, visual acuity of 20/25 or better, and had no concomitant ocular disease, systemic disease or systemic medication known to affect the visual field. The 10-2 test pattern with SITA Standard was used to test differential light sensitivity. Locations with pattern deviation probability values of <5% were identified in each POAG eye, and corresponding locations were eliminated from subsequent analysis for that POAG/control pair of eyes, in order to compensate for the effects of pattern loss on the most sensitive locations. For each POAG/control pair, the ten most sensitive remaining locations in each field were sequenced by sensitivity, ten (control - POAG) threshold differences were calculated, and the average and SD of the ten differences were determined.
The overall average of the sensitivity difference at the ten most sensitive locations was 1.9 ± 1.1 dB (significantly > 0, p<0.005). The 23 average differences were normally distributed (center: 2.1 dB; SD = 0.9 dB). For the individual pairs of eyes, the SD of the ten difference values ranged from 0.3 to 0.8 dB (ave = 0.6 dB).
Glaucoma patients with pattern visual field loss within 10 degrees of fixation also exhibit diffuse loss of sensitivity averaging approximately 2 dB. We have confirmed the 24-2 findings of Henson and extended them to the central 10-2 visual fields of patients with glaucoma.
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