April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Multifocal Electroretinography Ring Ratios in the Prediction of Macular Hole Formation
Author Affiliations & Notes
  • B. Varsanyi
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • R. Tuzson
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • B. V. Nagy
    Department of Mechatronics, Optics and Engineering Informatics, Budapest University of Technology and Economics, Budapest, Hungary
  • R. Vámos
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • B. Lesch
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • Á. Farkas
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • M. Ferencz
    Department of Ophthalmology, Semmelweis University, Budapest, Hungary
  • Footnotes
    Commercial Relationships  B. Varsanyi, None; R. Tuzson, None; B.V. Nagy, None; R. Vámos, None; B. Lesch, None; Á. Farkas, None; M. Ferencz, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5308. doi:
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      B. Varsanyi, R. Tuzson, B. V. Nagy, R. Vámos, B. Lesch, Á. Farkas, M. Ferencz; Multifocal Electroretinography Ring Ratios in the Prediction of Macular Hole Formation. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5308.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Our aim was to investigate the predictive role of multifocal electroretinography (mfERG) by analyzing the ring ratios in the fellow eye of patients with unilateral macular hole.

Methods: : 80 eyes of 40 patients with unilateral macular hole were examined by mfERG (RetiScan, Roland Consult, Germany). Ring ratios of the multifocal electroretinograms were calculated by correlating the central ring’s response density to that of the peripheral ones (R1/R2, R1/R3, R1/R4).After surgery, macular hole formation and follow-up of the macular morphology were recorded by optical coherence tomography (OCT). During the follow-up period, in 13 of 40 cases macular hole formation was detected in the previously intact fellow eye. Patients were divided into two groups according to this. The ring ratios of the two groups were compared and discriminant analysis was used to calculate the best separator function.

Results: : The two groups show statistically significant differences for the ratios R1/R2, R1/R3 and R1/R4 (p<0.01). The linear separation function for the cases were estimated with discriminant analysis providing correct classification of 80% based on the ratio R1/R2 and 82.5% using all three ratios as predictors.

Keywords: electroretinography: clinical • macular holes • detection 
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