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B. Varsanyi, R. Tuzson, B. V. Nagy, R. Vámos, B. Lesch, Á. Farkas, M. Ferencz; Multifocal Electroretinography Ring Ratios in the Prediction of Macular Hole Formation. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5308.
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Our aim was to investigate the predictive role of multifocal electroretinography (mfERG) by analyzing the ring ratios in the fellow eye of patients with unilateral macular hole.
80 eyes of 40 patients with unilateral macular hole were examined by mfERG (RetiScan, Roland Consult, Germany). Ring ratios of the multifocal electroretinograms were calculated by correlating the central ring’s response density to that of the peripheral ones (R1/R2, R1/R3, R1/R4).After surgery, macular hole formation and follow-up of the macular morphology were recorded by optical coherence tomography (OCT). During the follow-up period, in 13 of 40 cases macular hole formation was detected in the previously intact fellow eye. Patients were divided into two groups according to this. The ring ratios of the two groups were compared and discriminant analysis was used to calculate the best separator function.
The two groups show statistically significant differences for the ratios R1/R2, R1/R3 and R1/R4 (p<0.01). The linear separation function for the cases were estimated with discriminant analysis providing correct classification of 80% based on the ratio R1/R2 and 82.5% using all three ratios as predictors.
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