April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Investigating the Retinal Contribution to Short-Wavelength Colour Defect in Adolescents With Type I Diabetes
M. T. McFarlane; G. Mirabella; T. Wright; E. Lakhani; C. Westall
Author Affiliations & Notes
  • M. T. McFarlane
    Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
  • G. Mirabella
    Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
  • T. Wright
    Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
  • E. Lakhani
    Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
  • C. Westall
    Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
  • Footnotes
    Commercial Relationships  M.T. McFarlane, None; G. Mirabella, None; T. Wright, None; E. Lakhani, None; C. Westall, None.
  • Footnotes
    Support  Juvenile Diabetes Research Foundation (JDRF), Vision Science Research Program (VSRP)
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5313. doi:
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      M. T. McFarlane, G. Mirabella, T. Wright, E. Lakhani, C. Westall; Investigating the Retinal Contribution to Short-Wavelength Colour Defect in Adolescents With Type I Diabetes. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5313.

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Abstract

Purpose: : To determine if short-wavelength sensitivity loss found previously in adolescents with Type I Diabetes (T1D) and no evidence of diabetic retinopathy (Elia et al., IOVS 2005) is associated with a retinal defect at the level of the short-wavelength sensitive (S) cone pathways.

Methods: : Electrophysiological testing was performed in a cross-sectional, prospective study on 6 subjects (15 ± 1.76 years old) who had T1D for at least 5 years and 5 control subjects (19 ± 4.55 years old). All subjects underwent ophthalmological examination. Ambient blood glucose was monitored and maintained between 4-10mmol/L before and during testing. Short-wavelength electroretinograms (sERGs) were recorded using short-wavelength flashes (peak at 410nm) against an amber (594 nm) background. The primary outcome measure was implicit time of the b-wave. Chromatic visual evoked potentials (cVEPs) were recorded using the International 10/20 System of Electrode Placement. Short-wavelength (S), and long- and medium-wavelength (LM) colour stimuli consisted of vertical, photometric isoluminant sinusoidal gratings (1cyc/deg) at 20% colour contrast and were presented in a pattern onset (100ms)-offset (400ms) mode at 2Hz. The primary outcome measure was cVEP latency.

Results: : sERG implicit times were significantly delayed in adolescents with T1D in comparison to controls (p=0.003). In the same subjects, cVEP latencies to blue-yellow (tritan) stimuli were delayed in those with T1D in comparison to controls (p=0.007).

Conclusions: : S-cone visual pathways are selectively affected in adolescent subjects with T1D. sERG results indicate retinal dysfunction in the S-cone retinal pathways in adolescents with T1D. cVEP results indicate a defect in the short-wavelength pathway leading from the retina to the visual cortex in subjects with T1D. The cVEP deficit may be partially explained by S-cone deficit.

Keywords: diabetic retinopathy • color vision • electrophysiology: clinical 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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