Abstract
Purpose: :
To evaluate the changes in foveal thickness, fixation, and visual acuity (VA) after intravitreal bevacizumab or triamcinolone acetonide injection in patients with branch retinal vein occlusion (BRVO).
Methods: :
We prospectively examined 30 eyes of 30 patients with macular edema associated with BRVO. Thirty patients were treated with an intravitreal injection of either 4 mg of triamcinolone acetonide or 1.25 mg bevacizumab. Ophthalmic examinations were performed at baseline, 1 week, and 1, 3, and 6 months. The logarithm of the minimum angle of resolution (logMAR) VA, foveal thickness, and fixation were measured. Fixation was measured by microperimetry; good fixation was defined as fixation that exceeded 95% within the central 2-degree circle.
Results: :
The logMAR VA values were 0.66, 0.51, 0.47, 0.52, and 0.44 at baseline, 1 week, and 1, 3, and 6 months, respectively. The foveal thicknesses were 603, 353, 270, 380, and 287µm, respectively; the percentages of patients with good fixation were 53.3%, 63.3%, 80.0%, 70.0%, and 86.7% at each visit, respectively. The logMAR VA values and foveal thicknesses improved significantly after treatment. The foveal thicknesses improved first, followed by improvement of the fixation point and the VA.
Conclusions: :
The morphologic changes seemed to improve after intravitreal injection for BRVO and this was followed by functional improvement.
Clinical Trial: :
www.umin.ac.jp/ctr/index/htm UMIN000001546
Keywords: retina • vascular occlusion/vascular occlusive disease • visual fields