April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Long-term Light Scattering Measurements After Corneal Collagen Cross-Linking Using Riboflavin/UVA Treatment (CXL)
J. Merayo-Lloves; T. Blanco; J. Hincapie; R. Cantalapiedra; P. Perez-Merino; I. Alcalde; P. Gallego; S. del Olmo-Aguado; L. Ibares-Frias; S. Mar
Author Affiliations & Notes
  • J. Merayo-Lloves
    IOBA,
    University of Valladolid, Valladolid, Spain
  • T. Blanco
    Schepens Eye Research Institute, Harvard University, Boston, Massachusetts
  • J. Hincapie
    IOBA,
    University of Valladolid, Valladolid, Spain
  • R. Cantalapiedra
    IOBA,
    Cell Biology and Histology,
    University of Valladolid, Valladolid, Spain
  • P. Perez-Merino
    IOBA,
    Cell Biology and Histology,
    University of Valladolid, Valladolid, Spain
  • I. Alcalde
    IOBA,
    University of Valladolid, Valladolid, Spain
  • P. Gallego
    IOBA,
    Cell Biology and Histology,
    University of Valladolid, Valladolid, Spain
  • S. del Olmo-Aguado
    IOBA,
    Cell Biology and Histology,
    University of Valladolid, Valladolid, Spain
  • L. Ibares-Frias
    IOBA,
    University of Valladolid, Valladolid, Spain
  • S. Mar
    University of Valladolid, Valladolid, Spain
  • Footnotes
    Commercial Relationships  J. Merayo-Lloves, None; T. Blanco, None; J. Hincapie, None; R. Cantalapiedra, None; P. Perez-Merino, None; I. Alcalde, None; P. Gallego, None; S. del Olmo-Aguado, None; L. Ibares-Frias, None; S. Mar, None.
  • Footnotes
    Support  Supported by a PROFIT Grant CIT-300100-2007-50 Ministry of Health of Spain
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5460. doi:
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      J. Merayo-Lloves, T. Blanco, J. Hincapie, R. Cantalapiedra, P. Perez-Merino, I. Alcalde, P. Gallego, S. del Olmo-Aguado, L. Ibares-Frias, S. Mar; Long-term Light Scattering Measurements After Corneal Collagen Cross-Linking Using Riboflavin/UVA Treatment (CXL). Invest. Ophthalmol. Vis. Sci. 2009;50(13):5460.

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Abstract

Purpose: : To evaluate the long-term effect of combined riboflavin-ultraviolet A (UVA) treatment (CXL) in the forward light scattering of the hen cornea.

Methods: : The corneas of the right eyes of eight Lohmann Classic hens were crosslinked by application of the photosensitizer riboflavin and exposure to UVA light (370 nm, 3 mW/cm2) for 30 minutes. The left fellow control eyes were deepithelialized. Direct transmittance and corneal light scattering were measured at 6 and 10 months using a scatterometer developed by our group. Differences between the crosslinked and deepithelializated eyes were compared with untreated control eyes. All eyes were fixed for histological analysis.

Results: : There was a significant decrease in forward light scattering after cross-linking over a time period of 6 to 10 months compared with the deepithelialization and the control groups.

Conclusions: : Riboflavin/UVA-induced collagen cross-linking leads to a long-term decrease in forward light scattering in the hen corneas which remains stable over time.

Keywords: refractive surgery • cornea: stroma and keratocytes 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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