April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Corneal Collagen Crosslinking With Riboflavin and Ultraviolet-A Light in Progressive Keratoconus
Author Affiliations & Notes
  • M. A. Jimenez
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • M. Jerez
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • P. Arriola
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • D. Diaz
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • R. Cuiña
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • M. Iradier
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • J. Benitez del Castillo
    Ophthalmology, Hospital Clinico San Carlos, Madrid, Spain
  • Footnotes
    Commercial Relationships  M.A. Jimenez, None; M. Jerez, None; P. Arriola, None; D. Diaz, None; R. Cuiña, None; M. Iradier, None; J. Benitez del Castillo, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5463. doi:
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    • Get Citation

      M. A. Jimenez, M. Jerez, P. Arriola, D. Diaz, R. Cuiña, M. Iradier, J. Benitez del Castillo; Corneal Collagen Crosslinking With Riboflavin and Ultraviolet-A Light in Progressive Keratoconus. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5463.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To report short term results in a study of corneal crosslinking (CXL) analysed with Pentacam (Oculus Optikgërate, Deutschland) in the management of progressive keratoconus.

Methods: : Crosslinking was performed using 0.1% riboflavin and ultraviolet A (UVA) irradiation. Radiant energy was 3 mW/cm2 for a 30 min exposure at 1 cm from the corneal apex. At each review, a full clinical ophthalmic examination was performed including refraction, best corrected visual acuity, corneal thickness, corneal topography and confocal microscopy.

Results: : The analysis included 10 eyes of 9 patients with a minimum follow up of three months. Topographic analysis showed a mean K reduction of 1.08 ± 0.65 diopters (D) in the central 3.0 mm. Statistical analysis of IOP, best corrected visual acuity and endothelial cell count did not show statistically significant differences (p>0.05). Mean central corneal thickness (CCT) measured with optical pachymetry showed a reduction of 24.87 ± 74.71 µm. At a minimum 3 months follow up none of the patients presented any complications or adverse events.

Conclusions: : Our short term results suggest that CXL is a minimum invasive procedure, with little stress for the patients, with few side effects. In this small cohort of patients we observed a reduction on the CCT measured with the Pentacam 3 months after the CXL

Keywords: keratoconus • topography • cornea: stroma and keratocytes 
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