April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Laboratory Intra-stromally Delivered Collagen Cross-Linking (iCCL) in an Advanced Bullous Keratopathy (BK) Model
Author Affiliations & Notes
  • D. Ng
    Department of Ophthalmology, New York University/MEETH, New York, New York
  • A. J. Kanellopoulos
    Department of Ophthalmology, New York University/MEETH, New York, New York
  • Footnotes
    Commercial Relationships  D. Ng, None; A.J. Kanellopoulos, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5466. doi:
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    • Get Citation

      D. Ng, A. J. Kanellopoulos; Laboratory Intra-stromally Delivered Collagen Cross-Linking (iCCL) in an Advanced Bullous Keratopathy (BK) Model. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5466.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : Evaluate a novel staged iCCL.

Methods: : In 10 eye bank corneas, 2 sequential femtosecond derived pockets were used for iCCL with UVA exposure at 15mW/cm2 for 7 minutes each.

Results: : After iCCL UVA/Sham exposure, the mean clarity was 3.25 + SD for group A and 3.50 + SD for group B, while the mean thickness was 580 + SD µm for group A and 710 + SD µm for group B.

Conclusions: : Staged UVA crosslinking (15mW/cm2) with intrastromal riboflavin may be a safe (no cornea scarring) and effective (marked reduction of edema) alternative method for managing bullous keratopathy.

Keywords: cornea: basic science • cornea: stroma and keratocytes • cornea: endothelium 
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