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M. Baumeister, O. K. Klaproth, J. Buehren, T. Kohnen; Aberrations of the Cornea Following Collagen Cross-Linking for Keratoconus. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5488.
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Collagen cross-linking with application of riboflavin and UV radiation may delay or halt the progression of keratoconus. This study examines the effects of the treatment on the corneal wavefront error.
Twenty eyes of 20 patients with Keratoconus received collagen cross-linking with riboflavin application and 30 min of UV radiation with a wavelength of 370 nm. Preoperatively and 1 and 6 months postoperatively, the corneal wavefront error was computed from axial keratometric topography data by Zernike decomposition over a pupil diameter of 6 mm.
Preoperative mean keratometric astigmatism was 5.37 +/- 2.36 D. Six months posoperatively it was 5.29 +/- 2.73 D (p=0.35). Total higher order aberrations were preoperatively 3.35 +/- 1.65 µm and after 6 months 3.31 +/- 1.79 µm (p= 0.116). Coma root mean square was 2.94 +/- 1.47 µm preoperatively and 2.75 +/- 1.38 µm after 6 months (p=0.047). The logarithm of the visual Strehl ratio of the optical transfer function with best sphero-cylindrical correction (BCVSOTF) was -1.50 +/- 0.26 before the procedure and -1.44 +/- 0.31 after 6 months (p=0.40).
Within the first 6 postoperative months, collagen cross-linking with riboflavin application and UVA irradiation does not significantly increase or decrease corneal wavefront aberrations.
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