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S. Keijser, R. J. W. Keizer de, A. Lelij van der, M. J. Jager, P. H. Nibbering; IL-10 Promotor Polymorphisms Associated With Susceptibility to and Severity of Bacterial Corneal Ulcers. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5537.
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In animal models for bacterial corneal ulcers, high IL-10 levels were associated with a better clinical outcome. We investigated whether IL-10 promotor polymorphisms, known to influence IL-10 expression in vitro, were associated with susceptibility to and/or clinical outcome of bacterial corneal ulcers.
IL-10 promotor polymorphisms C-819T, G-1082A, A-2763C, and A-2849G were determined in 83 patients with bacterial corneal ulcers and 115 healthy controls by restriction fragment length PCR analysis. For 63 patients and all healthy controls IL-10 haplotypes could be inferred using the program SNPHAP.
A significant underrepresentation of the A-2849A genotype was observed in the patient group compared to healthy controls. Both the -2763A allele and the IL-10.1 haplotype were associated with a poor clinical outcome. While the IL-10.2 haplotype was associated with a better clinical course.
IL-10 promotor polymorphisms that are associated with low IL-10 levels seem to protect against a bacterial corneal ulcer. Once a corneal ulcer has developed, IL-10 polymorphisms/haplotypes associated with a high IL-10 expression display a favorable outcome of bacterial corneal ulcers.
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