April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
The Adipokine Adiponectin Can Be Elevated in Graves’ Ophthalmopathy
Author Affiliations & Notes
  • D. A. Della Rocca
    Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • E. A. Maher
    Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • J. P. Milite
    Ophthalmology, The New York Eye and Ear Infirmary, New York, New York
  • M. G. Plagianos
    Ophthalmology, St. Luke's Roosevelt, New York, New York
  • S. M. Ahmad
    Ophthalmology, St. Luke's Roosevelt, New York, New York
  • E. Moy
    Ophthalmology, St. Luke's Roosevelt, New York, New York
  • P. E. Scherer
    Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, Texas
  • P. A. Latkany
    Ophthalmology, The New York Eye and Ear Infirmary/ St, Luke's Roosevelt, New York, New York
  • R. C. Della Rocca
    Ophthalmology, The New York Eye and Ear Infirmary/ St, Luke's Roosevelt, New York, New York
  • Footnotes
    Commercial Relationships  D.A. Della Rocca, None; E.A. Maher, None; J.P. Milite, None; M.G. Plagianos, None; S.M. Ahmad, None; E. Moy, None; P.E. Scherer, None; P.A. Latkany, None; R.C. Della Rocca, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5562. doi:https://doi.org/
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      D. A. Della Rocca, E. A. Maher, J. P. Milite, M. G. Plagianos, S. M. Ahmad, E. Moy, P. E. Scherer, P. A. Latkany, R. C. Della Rocca; The Adipokine Adiponectin Can Be Elevated in Graves’ Ophthalmopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5562. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : A transgenic mouse model with overexpression of the adipokine adiponectin resulted in progressive expansion of the retrobulbar fat pad leading to fulminant exophthalmos. We undertook a pilot study to determine if adiponectin levels in patients with Graves’ Ophthalmopathy are elevated as found in the transgenic mouse model.

Methods: : From a large urban ophthalmic plastics service 46 consecutive patients with Graves' Ophthalmolopathy had their mean serum adiponectin levels determined through an adiponectin ELISA. Clinical data was recorded using standardized criteria.

Results: : An ANOVA analysis found that mean adiponectin levels differed significantly between inactive and active Graves' disease patients (p=0.0458) and presence of diabetes (p=0.0054). Mean adiponectin level in the active disease group was 15.78 mg/L (SD=8.51), and in the inactive group it was 11.36 mg/L (SD=6.29).

Conclusions: : The adipokines such as adiponectin warrant further investigation regarding its role in the development of Graves’ ophthalmopathy and its clinical subtypes and concomitant diseases such as diabetes.

Keywords: orbit • proteins encoded by disease genes 
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