Performance of Polyquad, PHMB and Peroxide Solutions With Silicone Hydrogel Lenses

Abstract

Purpose: : To compare clinical performance, adverse events, physiological and subjective responses in lens care products used with various silicone hydrogel contact lenses.

Methods: : Participants [Px] used PQT (Polyquad/Tearglyde; Alcon), 3% H₂O₂ or PHMB (CIBA) with either galyfilcon A, senofilcon A, lotrafilcon B, lotrafilcon A, balafilcon A or comfilcon A over three months daily wear and overnight disinfection. Results of two separate analyses compare 236 Px using PQT to 292 Px using H₂O₂ and to 237 Px using PHMB.Clinical and subjective variables were collected and analysed using a linear mixed model at scheduled baseline, two week, one month and three month visits. Adverse event data was collected and analysed using a logistic regression model for both scheduled and unscheduled visits. Results are presented as percentage of Px and repeated observations within the same Px who participated in more than one trial, were controlled for in the statistical model.

Results: : PQT had significantly higher first-event incidence of significant corneal inflammatory events [CIE] compared to H₂O₂ (10.2% vs 0.7% p<0.01) and PHMB (10.2% vs 4.6% p=0.016) as well as a higher rate of solution induced corneal staining compared to H₂O₂ (16.5% vs. 1.7% p<0.01). No significant difference was observed between PQT and other solutions for mechanical adverse events (p>0.05).Significantly more Px agreed lenses were easier to handle when using H₂O₂ and PHMB compared to PQT (H₂O₂ : 94.7% vs. 84.2% p<0.01, PHMB: 93.4% vs 84.2% p=0.001). In addition, more Px using PHMB agreed lenses were comfortable on insertion (91.3% vs 85.5% p=0.049) and during the day (93.9% vs 86.8% p=0.01) compared to PQT.The above differences between the two solutions did not significantly interact with the lens types (p>0.05).

Conclusions: : The PQT solution had significantly more CIE and less favourable subjective responses when compared to either H₂O₂ or PHMB solution.

Clinical Trial: : www.anzctr.org.au ACTRN 12608000329369

Keywords: contact lens • clinical (human) or epidemiologic studies: prevalence/incidence • inflammation