April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
A New Diagnostic Approach to Orbital Lymphoproliferative Disease
M. A. Blasi; G. Savino; L. Balia; D. Colucci; M. G. Sammarco; E. Colangelo; C. G. Caputo; E. Balestrazzi
Author Affiliations & Notes
  • M. A. Blasi
    Ophthalmology, University of L Aquila, L'Aquila, Italy
  • G. Savino
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • L. Balia
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • D. Colucci
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • M. G. Sammarco
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • E. Colangelo
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • C. G. Caputo
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • E. Balestrazzi
    Department of Ophthalmology, Catholic University of Rome, Rome, Italy
  • Footnotes
    Commercial Relationships  M.A. Blasi, None; G. Savino, None; L. Balia, None; D. Colucci, None; M.G. Sammarco, None; E. Colangelo, None; C.G. Caputo, None; E. Balestrazzi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5729. doi:
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      M. A. Blasi, G. Savino, L. Balia, D. Colucci, M. G. Sammarco, E. Colangelo, C. G. Caputo, E. Balestrazzi; A New Diagnostic Approach to Orbital Lymphoproliferative Disease. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5729.

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Abstract

Purpose: : To describe the Fine needle Aspiration Cytology (FNAC) associated to Thin Prep (TP) technique as a new approach to Orbital Lymphoproliferative Disease (OLD).

Methods: : Fifteen patients with clinical and radiological suspicion of OLD underwent FNAC. The cellular material was processed with both traditional and Thin Prep2000TM methods (Cytyc Co., Marlborough, MA, U.S.A.) and stained with Papanicolaou stain. Immunohistochemical (IHC). Molecular investigations were carried out on the thin-layer slides when needed. All patients had subsequent incisional biopsies to confirm the cytological results.

Results: : The series included: 7 reactive lymphoid hyperplasias, 4 MALT (Mucosa Associated Lymphoid Tissue) lymphomas, 2 diffuse large B-cell lymphomas, 1 lymphoplasmacytic lymphoma, 1 follicular lymphoma. All cases diagnosed on preliminary FNAC evaluation were confirmed by final histopathological interpretation (15/15).

Conclusions: : TP technique should be considered as a new valid diagnostic approach to OLD that improves the diagnostic accuracy of orbital FNAC allowing determination of lesion subtype and selection of appropriate therapy.

Keywords: oncology • orbit • pathology techniques 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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