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P. Mehta, L. Webbeh, A. Manna, N. Manjunatha, O. Durrani; Lymphoproliferative Tumours of the Orbit: Analysis of the Clinical Features and Systemic Involvement. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5732.
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To analyse the clinical features, the histopathological type and systemic involvement of patients diagnosed with biopsy proven orbital lymphoproliferative tumours (OLT) in one centre in the United Kingdom.
This was a retrospective case note analysis of 30 patients seen in one centre over a period of 10 years from 1998 to 2008.
Of the 30 patients, 11 patients (37%) had B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT), which was the commonest histopathological type.The mean age at presentation was 63 years. The commonest presenting symptom was eyelid swelling, which was seen in 20 patients (67%). Mean follow-up was 40.3 months with a median of 33 months (range: 4 to 114 months). Four patients (13%) had bilateral disease of which 2 had mantle cell lymphoma and 2 had benign reactive lymphoid hyperplasia (BRLH). 3 of these patients were diagnosed with systemic lymphoma (SL) before developing orbital lymphoma. One had Hodgkin’s lymphoma and 2 had mantle cell lymphoma.Systemic involvement was absent in 25 patients (83%) at the time of presentation. Of these 25 patients, 2 (8%) went on to develop SL subsequently and died due to the SL (1 patient had MALT and the other had Diffuse large B-Cell Lymphoma). 4 patients (13%) had SL before being diagnosed with OLT and one patient (3%)was diagnosed to have SL simultaneous to OLT. Regression of the disease was seen in 23 patients (77%) following treatment but one patient later died of other causes. Five patients (16%) had recurrence for which they underwent further treatment and 2 patients (7%) died from the systemic lymphoma.
In our series of patients with OLT alone, 8% went on to develop SL and SL was significantly associated with bilateral disease.
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