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K. Umazume, K. Kasai, K. Kimura, Y. Usui, H. Goto; Review of Clinical Features of Orbital Tumor in 421 Cases From Single Institute. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5747. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To review 421 cases of orbital tumor at single institute in Japan.
421 cases of orbital tumors diagnosed at Tokyo Medical University Hospital from 1990 through 2008 were reviewed. We retrospectively studied frequency of the individual tumor, gender, laterality and distribution of the age.
Among the 421 cases, 323 cases (76%) were primary orbital tumor and 98 cases (24%) were secondary orbital tumor. In primary benign orbital tumor, the most frequent tumor was idiopathic orbital inflammation (IOI) (25%), followed by reactive lymphoid hyperplasia (6%), dermoid cyst (5%), pleomorphic adenoma (5%), cavernous hemangioma (4%), meningioma (3%), lymphangioma (2%), capirally hemangioma (2%). In primary malignant orbital tumor, the most frequent tumor was malignant lymphoma (8%), followed by adenoid cystic carcinoma (2%) and adenocarcinoma (2%) In secondary orbital tumor, the most frequent tumor was cystic lesion arising from paranasal sinus (8%), metastatic tumor (5%), malignant tumor of paranasal sinus (4%) and malignant lymphoma (4%). In gender, 46% were male and 54% were female. Unilateral tumor was 90% and bilateral tumors were 10%. Average age of benign and malignant primary tumor was 48±22 y.o. and 61±19 y.o. respectively. Average age of benign and malignant secondary tumor was 54±13 y.o. and 57±20 y.o. respectively. Age of primary malignant tumor was significantly older than age of benign.
The present study showed the most frequent orbital tumor was IOI. Because the diagnosis of IOI was basically made by clinical course including the response to corticosteroid, reactive lymphoid hyperplasia, low grade malignant lymphoma such as MALT lymphoma and other clinical entity may be included in the series of IOI. High incidence of malignant lymphoma in the orbit may be characteristic in Japan.
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