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O. Geyer, T. Arev-Fishelson, O. Sagiv, N. Mathalone, E. Segev, R. Peled, D. M. Silver; Retinal Nerve Fiber Layer Thickness in Patients with Obstructive Sleep Apnea Syndrome (OSAS). Invest. Ophthalmol. Vis. Sci. 2009;50(13):5837.
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© ARVO (1962-2015); The Authors (2016-present)
To study retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea syndrome (OSAS).
120 patients with OSAS were analyzed and compared with an age-matched control group of 104 subjects. Patients with OSAS underwent sleep studies to determine the respiratory disturbance index (RDI) during night sleep and were classified as having moderate (RDI, 20-39) or severe (RDI > 40) sleep apnea. The RNFL thickness was assessed by optical coherence tomography (StratusOCT) using the fast RNFL thickness (3.4) scan acquisition protocol.
Compared with the control group, eyes with OSAS showed a thinner RNFL in the 360 degrees average measurement (101.52+/-11.3µ, 101.38+/-11.3µ for control right eye and left eye respectively and 97.86+/-12.03µ, 96.5+/-12.13µ for OSAS in the right eye and left eye respectively, p=0.02) and in the superior (p=0.034) and inferior (p=0.03) quadrants in the right eye and superior (p=0.03) and temporal (p=0.02) quadrants in the left eye. There were no correlations between the RDI and any of the RNFL measurements on the OSAS eyes.
RNFL thickness was not correlated with the severity of OSAS; however, the thickness of RNFL was reduced in patients with OSAS compared to controls by less than 5µ (5%). The clinical significance of this change needs to be determined.
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