April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Retinal Capillary Blood Flow Correlates With Central Retinal Artery Vascular Resistance in Glaucoma Patients
L. J. McCranor; A. Harris; B. Siesky; A. Moss; L. Cantor; J. Abrams; D. WuDunn; M. Pickett; R. Ehrlich
Author Affiliations & Notes
  • L. J. McCranor
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • A. Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • B. Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • A. Moss
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • L. Cantor
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • J. Abrams
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • D. WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • M. Pickett
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • R. Ehrlich
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Footnotes
    Commercial Relationships  L.J. McCranor, None; A. Harris, None; B. Siesky, None; A. Moss, None; L. Cantor, None; J. Abrams, None; D. WuDunn, None; M. Pickett, None; R. Ehrlich, None.
  • Footnotes
    Support  Pfizer and Research to Prevent Blindness (RPB)
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5871. doi:
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      L. J. McCranor, A. Harris, B. Siesky, A. Moss, L. Cantor, J. Abrams, D. WuDunn, M. Pickett, R. Ehrlich; Retinal Capillary Blood Flow Correlates With Central Retinal Artery Vascular Resistance in Glaucoma Patients. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5871.

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Abstract

Purpose: : To compare retinal capillary blood flow with ophthalmic and central retinal artery blood flow and vascular resistance in primary open angle glaucoma (OAG) patients participating in the Indianapolis Glaucoma Progression Study (IGPS).

Methods: : An analysis of 40 patients with OAG (mean age 62.9 (10.2); 18 female) participating in the IGPS was performed to compare retinal capillary blood flow with the blood vessels supplying these tissues. Retinal capillary blood flow was assessed using Heidelberg retinal flowmetry (HRF) imaging and the pixel-by-pixel analysis method to determine mean retinal capillary blood flow and the percentage of pixels with zero blood flow (representing no capillary blood flow). Immediately following HRF, color Doppler imaging (CDI) of the ophthalmic (OA) and central retinal arteries (CRA) was performed. The peak systolic velocity (PSV), end diastolic velocity (EDV) and Pourcelot’s vascular resistance (RI) of each vessel were assessed. Correlations between HRF and CDI parameters were determined by linear regression. Pearson correlation coefficients were utilized to assess the strength of the associations. P values <0.05 were considered statistically significant.

Results: : In the CRA, a decrease in the RI significantly correlated with an increase in the percentage of zero-flow pixels (r=-0.20; p=0.037). The RI of the OA was not significantly correlated with the percentage of zero-flow pixels (r=0.0; p=0.5). Mean retinal capillary flow was not significantly correlated with the hemodynamics of either vessel. PSV and EDV of the OA and CRA were not significantly correlated with mean retinal capillary flow or the percentage of zero blood flow pixels.

Conclusions: : This data suggests that the vascular resistance of the CRA decreases in response to lower retinal capillary blood flow of OAG patients. Conversely, vascular resistance of the OA is apparently not affected by changes in retinal capillary circulation in OAG patients.

Keywords: retina • blood supply • imaging/image analysis: non-clinical 
© 2009, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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