April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Retinal Inflammatory Markers in Diabetic Retinopathy
Author Affiliations & Notes
  • S. Johnsen-Soriano
    FOM, Valencia, Spain
  • M. Sancho-Tello
    FOM, Valencia, Spain
  • E. Arnal
    FOM, Valencia, Spain
  • A. Navea
    FOM, Valencia, Spain
  • M. Diaz-Llopis
    Universitat de Valencia, Valencia, Spain
  • F. Bosch-Morell
    FOM, Valencia, Spain
    CEU-UCH, Valencia, Spain
  • F. Romero
    FOM, Valencia, Spain
    CEU-UCH, Valencia, Spain
  • Footnotes
    Commercial Relationships  S. Johnsen-Soriano, None; M. Sancho-Tello, None; E. Arnal, None; A. Navea, None; M. Diaz-Llopis, None; F. Bosch-Morell, None; F. Romero, None.
  • Footnotes
    Support  GVPRE/2008/353
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5893. doi:
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      S. Johnsen-Soriano, M. Sancho-Tello, E. Arnal, A. Navea, M. Diaz-Llopis, F. Bosch-Morell, F. Romero; Retinal Inflammatory Markers in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5893.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To study T-helper cell cytokine profiles of naive chemokine and cytokine in retinal tissue of diabetic subjects.

Methods: : Cytokines (interleukin IL-1a, IL-1b, IL-2, IL-4, IL-6, IL-10, TNFa, GM-CSF, interferon [IFN]-gamma) and Chemokines (MIP-1a, MIP-2, MIP-3a, MCP-1, GRO/KC, RANTES, Fractalkine), in addition to tyrosine nitration were measured in retinal homogenate obtained from Long Evans rats with five months experimental diabetes.

Results: : The Th1 cytokines; Interleukin-2 and INF-g, in addition to NO production were found to be significantly elevated in diabetic rat retina. None of the other cytokines and nor chemokines studied were affected by the diabetic condition.

Conclusions: : Immunoregulatory cytokines belonging to the TH-1 group (IL-2 and IFN-g) were detected in retinal homogenate from rats with experimental diabetes, indicating a T-helper type 1 response and suggesting novel roles for IL-2 and INF-gamma. Moreover, the NO production was significantly elevated in the diabetic retina, supporting the concept of an inflammatory element in the development of diabetic retinopathy.

Keywords: diabetic retinopathy • inflammation • cytokines/chemokines 

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