April 2009
Volume 50, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2009
Barriers of Sclera, Chorioidea and Rpe in Periocular Drug Delivery: A Simulation Study
Author Affiliations & Notes
  • A. Urtti
    Centre for Drug Research, Univ of Helsinki,, Helsinki, Finland
  • E. Mannermaa
    Department of Pharmaceutics, Univ of Kuopio, Kuopio, Finland
  • N. Valkonen
    Department of Pharmaceutics, Univ of Kuopio, Kuopio, Finland
  • V.-P. Ranta
    Department of Pharmaceutics, Univ of Kuopio, Kuopio, Finland
  • Footnotes
    Commercial Relationships  A. Urtti, None; E. Mannermaa, None; N. Valkonen, None; V.-P. Ranta, None.
  • Footnotes
    Support  Academy of Finland
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 5973. doi:https://doi.org/
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      A. Urtti, E. Mannermaa, N. Valkonen, V.-P. Ranta; Barriers of Sclera, Chorioidea and Rpe in Periocular Drug Delivery: A Simulation Study. Invest. Ophthalmol. Vis. Sci. 2009;50(13):5973. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the roles of the barriers of periocular drug delivery to the retina and vitreous.

Methods: : The barriers were evaluated by using kinetic simulations that were based on experimental data. The permeability data of the isolated sclera and retinal pigment epithelium (RPE) were collected. The transfer rate of compounds from chorioidea to the plasma was calculated based on in vivo experiments. The sclera and RPE permeability were incorporated to the model as well as the drug clearance from the chorioidea. The model was built using STELLA simulation software and it includes sclera, chorioidea and RPE. Clearance by the chorioidea was estimated using diffusivity in the tissue and porosity of the capillaries.

Results: : The model describes accurately the individual barriers (sclera, chorioidea, RPE). The simulations with the complete model with all components reveal that the role of sclera as barrier is not substantial. The role of chorioidea is significant as most of the drug is cleared by the the blood flow. RPE is significant barrier particularly for the hydrophilic drugs. The model was used to simulate drug concentrations in the chorioidea and retina.

Keywords: retinal pigment epithelium • choroid • sclera 
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