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S. Machida, K. Tamada, T. Oikawa, D. Yokoyama, D. Kurosaka; Diagnostic Ability of Photopic Negative Response of Full-Field and Focal Electoretinograms in Detecting Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2009;50(13):6192.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate diagnostic ability of the photopic negative response (PhNR) of the full-field and focal electroretinograms (ERG) in detecting glaucomatous eyes at various degree of visual field defect.
One hundred eyes of 73 patients with open angle glaucoma and 40 eyes of 40 normal controls were studied. The full-field cone ERGs were elicited by red stimuli on a blue background. The focal ERGs were elicited by a 15° white stimulus spot centered on the macular region, or on the supero-temporal or the infero-temporal areas of the macula. The receiver operating characteristic (ROC) curves were determined for the PhNR of the full-field and focal ERGs.
In patients with early and intermediate glaucoma, the areas under the ROC curves (AUCs) were significantly larger for the PhNR amplitude and PhNR/b-wave amplitude ratio of the focal ERGs than those of the full-field ERGs. In advanced glaucoma, there was no difference in the AUCs between the focal and full-field ERGs. The specificity was over 90% for the full-field and focal PhNR when using optimal cut-off values. The sensitivity was 94.3% in eyes with early glaucoma for the PhNR amplitude and PhNR/b-wave amplitude ratio of the focal ERG, respectively, while the sensitivity was 34.3% and 25.7% for the full-field ERGs.
These results indicate that the focal PhNR could be a good indicator in detecting early and intermediate glaucomatous eyes. However, in advanced glaucoma diagnostic ability of the full-field PhNR is equivalent to that of the focal PhNR.
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