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S. W. Wong, N. J. Coletta, D. Troilo; A Study on Marmoset Foveal Morphology using Fourier-Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2009;50(13):6208.
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© ARVO (1962-2015); The Authors (2016-present)
The common marmoset (Callithrix jacchus) is a New World primate used as a model for studying eye development, visual pathways, and retinal anatomy. The aim of this study was to examine foveal retinal thickness of the marmoset during periods of early growth using the Optovue RTVue Fourier Domain-OCT.
Eleven eyes of marmosets aged 54 to 402 days were examined in this study. Spherical equivalent refractions were measured using an autorefractor (Nidek) and ranged from -2.61 D to 1.38 D (mean ± s.d., -1.13 D ± 1.14 D). OCT foveal scans were taken using the MM6 scan pattern that consists of twelve 6-mm long radial line scans delivered in 0.27 sec. Fixation was monitored using live video of the fundus image and live OCT sections. The fovea was identified by the presence of a clear foveal pit and a prominent region of cone outer segment thickness. Two vertical scans were evaluated with software caliper tools to determine foveal and parafoveal retinal thickness and repeatability of the thickness measurements.
Minimum central foveal thickness repeatability had a difference mean of 1.36µm and a 95% CI of -12.83 to 10.12µm. Minimum thickness values ranged from 192.5 to 216.0µm (204.6µm ± 6.41µm) and were not significantly correlated with age (R2=0.2875; p=0.09). Maximum parafoveal thickness values ranged from 286.0 to 334.5µm (307.0µm ± 17.4µm) and showed a significant positive correlation with age (R2=0.8229; p<0.001). Minimum central thickness was subtracted from the maximum parafoveal thickness to obtain an estimate of pit depth for each marmoset. Values ranged from 79.0 to 123.0µm (102.4µm ± 14.8µm) and showed a significant positive correlation with age (R2=0.6974; p=0.001).
OCT thickness measurements of marmoset fovea were highly repeatable. This study suggests there is an increase in retinal thickness at the parafovea and an increase in foveal pit depth as the young marmoset eye develops postnatally.
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