April 2009
Volume 50, Issue 13
ARVO Annual Meeting Abstract  |   April 2009
Serum IgE Levels in Patients With Allergic Conjunctivitis and Contact Lens Wearers
Author Affiliations & Notes
  • O. Gurses
    Middle East Technical University, Oran ankara, Turkey
  • N. Taheri
    Middle East Technical University, Oran ankara, Turkey
  • Footnotes
    Commercial Relationships  O. Gurses, None; N. Taheri, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 6321. doi:
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      O. Gurses, N. Taheri; Serum IgE Levels in Patients With Allergic Conjunctivitis and Contact Lens Wearers. Invest. Ophthalmol. Vis. Sci. 2009;50(13):6321.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To determine the differences of total and specific serum IgE levels between contact lens wearers and patients with allergic conjunctivitis (AC), and to evaluate the correlation of total serum IgE level with contact lens (CL) wearing time.

Methods: : This is a case-control study involving 25 CL wearers, 25 patients with AC and 25 age and sex-matched controls. The subjects enrolled in this study according to the Declaration of Helsinki. The control subjects have no ocular pathologies other than refractive errors. CL wearers have conventional hydrogel lenses without any CL-related problems, and they have normal slit-lamp examination findings. The patients with AC have been diagnosed as either seasonal allergic conjunctivitis (SAC) or perennial allergic conjunctivits (PAC) according to their past histories, and clinical signs and symptoms. They have not been receiving any anti-allergic treatment. Total serum IgE levels were detected by using enzyme-linked immunosorbent assay. Specific serum IgE analysis against indoor and outdoor allergens were studied by using immunofluorescence assay for the subjects whose total serum IgE levels were greater than 100 IU/ml. Statistical analysis was done by using SPSS 15.0 for Windows. Pearson’s and Spearmann’s correlations were used for bivariate analysis. Statistically significance was accepted at the 0.05 level.

Results: : 8 (32%) patients with AC was diagnosed as PAC, and 17 (68%) patients was diagnosed as SAC. The range and mean (SD) levels of total serum IgE of controls, CL wearers and patients with AC were19-85 IU/ml and 36.36 (24.98), 16-551 IU/ml and 63.68 (107.09), 36-1015 IU/ml and 227.40 (288.60) respectively. The mean (SD) duration of CL wearing time was 10.56 (3.39) hours/day. Statistically significant correlation was found between total serum IgE level of CL wearers and CL wearing time (Pearson’s correlation coefficient = 0.863, Spearmann’s correlation coefficient = 0.626, correlation is significant at the 0.01 level). The serum specific IgE detected in CL wearers was most commonly against outdoor allergens. The serum specific IgE detected in patients wih AC was against both indoor and outdoor allergens. There was no detectable serum specific IgE in controls.

Conclusions: : The increase in mean level of total serum IgE was greater in patients with AC than in CL wearers when compared to controls. Our study revealed for the first time a statistically significant correlation between total serum IgE levels of CL wearers and CL wearing time. Our study also revealed a rise in serum specific IgE levels against different allergens both in CL wearers and patients with AC.

Keywords: clinical laboratory testing • conjunctivitis • contact lens 

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