April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Day and Night Differences in Aqueous Humor Dynamics and IOP in Ocular Hypertensive Patients Treated With Dorzolamide
Author Affiliations & Notes
  • S. Rai
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • S. Fan
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • V. Gulati
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • M. Zhao
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • H. Liu
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • C. B. Camras
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • C. B. Toris
    Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska
  • Footnotes
    Commercial Relationships  S. Rai, None; S. Fan, None; V. Gulati, None; M. Zhao, None; H. Liu, None; C.B. Camras, None; C.B. Toris, None.
  • Footnotes
    Support  Supported by an unrestricted grant from Pfizer; Research to Prevent Blindness
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 146. doi:https://doi.org/
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      S. Rai, S. Fan, V. Gulati, M. Zhao, H. Liu, C. B. Camras, C. B. Toris; Day and Night Differences in Aqueous Humor Dynamics and IOP in Ocular Hypertensive Patients Treated With Dorzolamide. Invest. Ophthalmol. Vis. Sci. 2010;51(13):146. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the effect of topical dorzolamide on intraocular pressure (IOP) and aqueous humor dynamics during the day and night in patients with ocular hypertension.

Methods: : Thirty patients were enrolled in the 4-visit randomized, double-masked study following screening and 6 weeks of washout. On the two daytime visits from 9 AM to 3 PM (baseline and following two weeks of twice daily dosing of drug), intraocular pressure (IOP) was determined by pneumatonometry, aqueous flow (Fa) and outflow facility by fluorophotometry (Cfl), episcleral venous pressure (Pev) by venomanometry and outflow facility again by two minute tonography (Cton), central corneal thickness (CCT) and anterior chamber depth (ACd) by pachymetry and blood pressure by sphygmomanometry. Two days after each daytime visit, all measurements except for Cfl and Pev were repeated between the hours of 10 PM and 5 AM. Uveoscleral outflow was calculated by the Goldmann equation. Baseline and dorzolamide treatment were compared using two-tailed paired t-tests.

Results: : Dorzolamide significantly (p<0.001) reduced IOP by 16% at 11AM (two hours after the previous dose) but not at 9 AM (12 hours after the previous dose, 7% drop, p=0.07) or at any IOP overnight (10 PM, midnight, 2 AM, 5 AM). Compared to baseline, dorzolamide during the day reduced aqueous flow by 16% (p=0.03). Dorzolamide did not change any of the day versus night differences in IOP and aqueous humor dynamics found at baseline (reduced Fa and Fu and increased CCT). Physiological nighttime suppression of Fa seen at baseline was not decreased further by dorzolamide use (47%, p<0.001).

Conclusions: : Dorzolamide reduced IOP during the day in ocular hypertensive patients by reducing aqueous flow. It had no effect on IOP or aqueous humor dynamics at night nor did it affect CCT, ACd or blood pressure day or night.

Clinical Trial: : www.clinicaltrials.gov NCT00572936

Keywords: aqueous • drug toxicity/drug effects • intraocular pressure 
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