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S. Sawaguchi, H. Sakai, Y. Arakaki, I. Medoruma, E. Tomoyose; Effect of Anti-Glaucoma Therapy on 24-Hour Intraocular Pressure for Different Types of Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):177.
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To investigate the effect of combined therapy of latanoprost and brinzolamide on 24-hour intraocular pressure control(IOP) for primary glaucoma patients with open angle and angle closure.
Included subjects were 14 glaucoma patients with open angle eyes(OA group) and 6 patients with angle closure eyes after laser iridotomy(AC group)(baseline IOP>/= 18mmHg) with latanoprost monotherapy. Brinzolamide twice daily were then added for 4 weeks and 24-hour IOP was then measured for each 3 hours interval.
Baseline IOP was 20.3+/-1.5mmHg for OA group and 19.3+/-0.8mmHg for AC group, respectively(P=0.16). Average 24-hour IOP after administration of brinzolamide was significantly lowered to 16.3+/-1.5mmHg for OA group and 16.4+/-2.6mmHg for AC group, respectively. There was no significant intergroup difference(P=0.92). Average IOP reduction at day time and night time was 3.5mmHg and 4.4mmHg for OA group and 3.7mmHg and 2.2mmHg for AC group, respectively. Average IOP reduction at night time appeared to be less effective for AC group, however, was not significant(P=0.052). OA group showed significant IOP reduction for every time points, however, no significant IOP reduction was evident at 21(P=0.14),24(P=0.85), and 6 o'clock(P=0.36) for AC group, respectively.
We need to pay more attention for the night time IOP fluctuation for angle closure eyes even after LI and medical treatment.
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