April 2010
Volume 51, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2010
Long Term Effect of Latanoprost on Central Corneal Thickness in Normal Tension Glaucoma
Author Affiliations & Notes
  • B. J. Cho
    Ophthalmology, Konkuk University Hospital, Seoul, Republic of Korea
  • W. B. Cho
    Ophthalmology, Konkuk University Hospital, Seoul, Republic of Korea
  • H. J. Kim
    Ophthalmology, Konkuk University Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  B.J. Cho, None; W.B. Cho, None; H.J. Kim, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science April 2010, Vol.51, 179. doi:
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      B. J. Cho, W. B. Cho, H. J. Kim; Long Term Effect of Latanoprost on Central Corneal Thickness in Normal Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):179.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate long term effect of latanoprost on central corneal thickness (CCT) in patients with normal tension glaucoma.

Methods: : This was a retrospective study and included 166 total patients, 128 with normal tension glaucoma (NTG), 38 with glaucoma suspect, suspicious disc with normal visual field and IOP less than 21mmHg as control group. Patients with newly diagnosed normal tension glaucoma and without any previous topical glaucomaouts treatment were followed up more than 24 months and received latanoprost 0.005% monotherapy. CCT measurements were performed with ultrasound pachymeter. CCT measurements before treatment and 24 months after treatment were analyzed.

Results: : There were no significant differences between latanoprost group and control group for sex, age, baseline IOP, and CCT. A statistically significant reduction in mean CCT was observed in latanoprost group (n=128, 535.5±37.9 vs 530.1±36.4µm, p<0.001) but not in control group (n=38, 543.1±40.2 vs 542.6±37.0µm, p=0.786).

Conclusions: : Long term use with latanoprost may decrease CCT in patients with normal tension glaucoma. Therefore, clinicians must pay attention to longitudinal CCT variations that may arise throughout the follow-up period for a proper IOP targeting.

Keywords: cornea: clinical science • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • drug toxicity/drug effects 
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