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B. J. Cho, W. B. Cho, H. J. Kim; Long Term Effect of Latanoprost on Central Corneal Thickness in Normal Tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):179.
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To evaluate long term effect of latanoprost on central corneal thickness (CCT) in patients with normal tension glaucoma.
This was a retrospective study and included 166 total patients, 128 with normal tension glaucoma (NTG), 38 with glaucoma suspect, suspicious disc with normal visual field and IOP less than 21mmHg as control group. Patients with newly diagnosed normal tension glaucoma and without any previous topical glaucomaouts treatment were followed up more than 24 months and received latanoprost 0.005% monotherapy. CCT measurements were performed with ultrasound pachymeter. CCT measurements before treatment and 24 months after treatment were analyzed.
There were no significant differences between latanoprost group and control group for sex, age, baseline IOP, and CCT. A statistically significant reduction in mean CCT was observed in latanoprost group (n=128, 535.5±37.9 vs 530.1±36.4µm, p<0.001) but not in control group (n=38, 543.1±40.2 vs 542.6±37.0µm, p=0.786).
Long term use with latanoprost may decrease CCT in patients with normal tension glaucoma. Therefore, clinicians must pay attention to longitudinal CCT variations that may arise throughout the follow-up period for a proper IOP targeting.
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