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A. Usui, A. Mizota, I. Kimura, O. Miyauchi, I. Takahashi, M. Tanaka; 24-Hour Intraocular Pressure With Dorzolamide Added to Latanoprost in Primary Open- Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2010;51(13):202.
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© ARVO (1962-2015); The Authors (2016-present)
To study the effect of dorzolamide added to latanoprost monotherapy to the 24 hour intraocular pressure (IOP) change, and the effect of visual field change after 1 year in primary open angle glaucoma patients.
Patients who were treated with latanoprost monotherapy and had IOP controlled under 21mmHg were enrolled in the present study. To know the baseline 24-hour variation of IOP with latanoprost monotherapy after the use of latanoprost for more than 4weeks, IOP was measured at 1, 3, 7, 10, 13, 16, 19, 23 o’clock. Four weeks after adding dorzolamide, 24-hour variation of IOP was evaluated with same time schedule. Visual field tests by Humphrey automated static perimeter program 30-2 and IOP were evaluated after 1 year. This study was approved ethical committee in Juntendo University Urayasu Hospital. Analysis of variance(ANOVA) and Wilcoxon signed-rank test were used for statistical analysis.
In the comparison of 24-hour variation of IOP before and after adding dorzolamide, IOP values were significantly reduced at 1, 3, 7, 16, 19 and 23 o’ clock. The degree of IOP reduction was greater in midnight (1, 3, 23 o’ clock) than in daytime significantly. In the comparison of 24-hour mean IOP before and after adding dorzolamide, the mean 24-hour IOP was reduced 1.4mmHg(percentage of reduction: 10.6%). Average IOP, MD and PSD values by Humphrey automated static perimeter did not indicate statistically significant difference from the time when 4 weeks after adding dorzolamide.
These results suggest that dorzolamide added to latanoprost lowers IOP at all measurement time points, and the degree of reduction was greater at night than daytime especially, and showed 1-year efficacy of IOP reduction and visual field stability.
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